Anatomical Pathology Interesting Case Conference

Date of Presentation:7/12/2024

Attending pathologist: Anil Parwani, MD, PhD, MBA

Presented by: Simran Chandawarkar, BS

Organ:Kidney

HISTORY:

Male in his 70’s presented with renal mass

6.5 cm mass

Tan gray, necrotic tumor

No evidence of neoplasia in 2 lymph nodes

A nephrectomy was performed

GROSS:

Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue

What is the most likely diagnosis?

  1. Translocation-associated RCC
  2. Chromophobe RCC
  3. SMARCB1 (INI1)-deficient renal cell carcinoma
  4. SDHB deficient RCC
SMARCB1 (INI1)-deficient renal cell carcinoma

CASE SUMMARY