Anatomical Pathology Interesting Case Conference

Date of Presentation:8/21/2025

Attending pathologist: Anil Parwani, MD, PhD, MBA

Presented by: Rebecca Reese, BS, MLS (ASCP)

Prepared by: Rebecca Reese, BS, MLS (ASCP)

Organ:Prostate

HISTORY:

Patient is a male in his 50’s with history of adenocarcinoma of the prostate s/p treatments of external beam radiation therapy (EBRT) and 2-years of androgen deprivation therapy who presented with PSA elevation following testosterone recovery. The patient proceeded with MRI-guided prostate biopsy.

Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue

What is the most likely diagnosis?

  1. Prostatic adenocarcinoma with radiation changes
  2. Prostatic adenocarcinoma, Gleason Grade 3+4=7
  3. Androgen deprivation effect
  4. Ductal adenocarcinoma of the prostate
Prostatic adenocarcinoma with radiation changes

CASE SUMMARY