Date of Presentation:8/27/2025

Attending pathologist: Anil Parwani, MD, PhD, MBA

Presented by: Akansha Deshwal, MD

Prepared by: Nishant Rangwani, BS, Briggs Ham BS, Gibson Hohberg, BS

Organ:Prostate

HISTORY:

The patient is a female in her 80s with a past medical history of right breast cancer (s/p mastectomy), renal cell carcinoma, atrial fibrillation, hypertension, GERD, and hiatal hernia.

She presented with complaints of gross hematuria, weight loss, and decreased appetite.

Exam under anesthesia revealed palpable mass within the bladder, mobile, firmness at the bladder neck/proximal urethra.

Cystoscopy revealed a large bladder mass at dome measuring 6 cm diameter. This mass encompassed the bladder neck circumferentially and seemed pedunculated on a stalk.

The patient underwent TURBT (transurethral resection of bladder tumor).

The specimen was received as multiple pink-tan, irregular-shaped fragments of rubbery tissue, measuring 9.4 x 9.0 x 2.0 cm in aggregate.

GROSS:

Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue

What is the most likely diagnosis?

  1. Inflammatory myofibroblastic tumor
  2. Leiomyosarcoma
  3. Urothelial carcinoma with sarcomatoid differentiation
  4. Malignant fibrous histiocytoma
Leiomyosarcoma