Anatomical Pathology Interesting Case Conference

Date of Presentation:2/23/2021

Attending pathologist: Anil Parwani, MD, PhD

Presented by: Bindu Challa, MD

Prepared by: Bindu Challa, MD

Organ:Bladder

HISTORY:

A male in his 50s presents with epigastric pain and early satiety. CT scan showed 1.1 cm enhancing bladder mass. Transurethral resection of bladder tumor (TURBT) showed a 3-4 cm bladder tumor involving the right wall.

GROSS:

Received in formalin labelled “bladder tumor” are multiple fragments of tan-brown soft tissue measuring 2.3 cm x 2. cm x 0.7 cm.

Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue

AE1/AE3, p40, NKX3.1 stains were also done and read as negative.

What is the most likely diagnosis?

  1. Malignant melanoma
  2. Metastatic renal cell carcinoma
  3. Carcinoid tumor
  4. Paraganglioma of urinary bladder
  5. Nested variant of urothelial carcinoma
Paraganglioma of urinary bladder

CASE SUMMARY