Date of Presentation:3/24/2021

Attending pathologist: Anil Parwani, MD, PhD

Presented by: Bindu Challa, MD

Prepared by: Bindu Challa, MD

Organ:Kidney

HISTORY:

A male patient in his early 20s presents with right flank pain and gross hematuria. CT abdomen and pelvis showed a mass in lower pole of right kidney. MRI abdomen showed heterogenous, irregular, hypovascular mass measuring 4.4cm x 3.4 cm x 3.4 cm and mild hydronephrosis in right kidney.

GROSS:

Immunohistochemical stains were also positive for FH, SDHB, HNF1, AE1/AE3 (weak,focal), PAX8, INI1 and negative for OCT3/4 and CK7.

What is the most likely diagnosis?

  1. Clear cell renal cell carcinoma
  2. Clear cell papillary renal cell carcinoma
  3. Renal cell carcinoma, MITF/TFE3 family translocation associated subtype
  4. Epithelioid angiomyolipoma
  5. Clear cell sarcoma
Renal cell carcinoma, MITF/TFE3 family translocation associated subtype