Date of Presentation:8/4/2023

Attending pathologist: Anil Parwani, MD, PhD, MBA

Presented by: Amr Soliman, MBBCh

Prepared by: Himani Kumar, MD,
Muhammad Abdulwaasey, MBBS

Organ:Kidney

HISTORY:

A female in her 30s with a history of right flank pain, hypertension, anxiety, depression, migraines, tobacco use and hidradenitis.

CT Abdomen with contrast revealed 18.2 cm complex right renal cystic mass concerning for neoplasm. MRI Abdomen revealed a large and complex, hemorrhagic renal lesion on the right with a significant amount of hemorrhagic internal debris, measuring approximately 19.4 x 9.8 x 16.6 cm. A complex, enhancing and lobulated component of this cystic mass is seen at the medial margin, measuring 8 x 7 cm. The remaining majority of the complex hemorrhagic mass demonstrates no significant enhancement.

Slides were received from outside institute for consult.

GROSS:

Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue

What is the most likely diagnosis?

  1. Fumarate Hydratase-Deficient Renal Cell Carcinoma
  2. Clear cell carcinoma
  3. Papillary RCC
  4. Unclassified renal cell carcinoma
Fumarate Hydratase-Deficient Renal Cell Carcinoma