Sujit Basu, MD, PhD is a Professor in the Division of Experimental Pathology and Division of Medical Oncology (Internal Medicine). Dr. Basu received his medical degree and Ph.D. from University of Calcutta, India and has been trained as a medical oncologist. He completed his postdoctoral research work in the Department of Molecular Genetics at the University of Illinois at Chicago and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School in Boston. Dr. Basu was an Assistant Professor at Mayo Clinic (Rochester) prior to joining Ohio State University in 2008. Dr. Basu’s research is primarily focused to study cancer biology (tumor microenvironment, experimental therapeutics and neural regulation of tumorigenesis), angiogenesis, vasculogenesis and immunity (neural immune interactions).
Dr. Basu's research is supported by grants from the National Institute of Health, DOD and Research Foundations.
Academic and Medical Appointments
2013-Present Professor of Pathology and Medical Oncology, The Ohio State University Medical Center, Columbus, OH
2017-Present Director of Translational Research
Education and Training
1985-1996 M.D. - Ph.D., University of Calcutta, India
1991-1995 Ph.D. research work, Department of Medical Oncology and Endocrinology, Regional National Cancer Institute of India, Kolkata, India (CNCI)
Search in PubMed
- Roy S, Lu K, Nayak MK, Bhuniya A, Ghosh T, Kundu S, Ghosh S, Baral R, Dasgupta PS, Basu S. Activation of D2 Dopamine Receptors in CD133+ve Cancer Stem Cells in Non-small Cell Lung Carcinoma Inhibits Proliferation, Clonogenic Ability, and Invasiveness of These Cells. J Biol Chem 292:435-445, 2017.
- Chakroborty D, Sarkar C, Lu K, Bhat M, Dasgupta PS, Basu S. Activation of Dopamine D1 receptors in Dermal Fibroblasts Restores VEGF-A Production by These Cells and Subsequent Angiogenesis in Diabetic Cutaneous Wound Tissues. Am J Pathol 186: 2260-2272, 2016.
- Liu JQ, Talebian F, Wu L, Liu Z, Li MS, Wu L, Zhu J, Markowitz J, Carson WE 3rd, Basu S, Bai XF. A Critical Role for CD200R Signaling in Limiting the Growth and Metastasis of CD200+ Melanoma. J Immunol 197:1489-1497, 2016.
- Lu K, Basu S. The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions. Sci Rep. 2015 Apr 10; 5:9642. doi: 10.1038/srep09642.
- Sarkar C, Chakroborty D, Dasgupta PS, Basu S. Dopamine is a safe antiangiogenic drug which can also prevent 5-fluorouracil induced neutropenia. Int J Cancer 137:744-749, 2015.
- Joseph M, Das M, Kanji S, Lu J, Aggarwal R, Chakroborty D, Sarkar C, Yu H, Mao HQ, Basu S, Pompili VJ, Das H. Retention of stemness and vasculogenic potential of human umbilical cord blood stem cells after repeated expansions on PES-nanofiber matrices. Biomaterials 35:8566-8575, 2014.
- Kanji S, Das M, Aggarwal R, Lu J, Joseph M, Basu S, Pompili VJ, Das H. Nanofiber-expanded human umbilical cord blood-derived CD34+ cell therapy accelerates murine cutaneous wound closure by attenuating pro-inflammatory factors and secreting IL-10. Stem Cell Res 12:275-288, 2014.
- Wang Z, Liu J-Q, Liu Z, Shen R, Basu S, Feng Y, Bai X-F. "Tumor-derived IL-35 promotes tumor growth via enhancing myeloid cell accumulation and angiogenesis." Journal of Immunology. 190:2415-2423, 2013
- Lu K, Chakroborty D, Sarkar C, Lu T, Xie Z, Liu Z, Basu S, "Triphala and its active constituent chebulinic acid are natural inhibitors of vascular endothelial growth factor - A mediated angiogenesis". PLos One 8: e43934, 2012
- Shome S, Dasgupta PS, Basu S. Dopamine regulates mobilization of mesenchymal stem cells during wound angiogenesis. PLoS One 7: e31682, 2012
- Chakroborty D, Sarkar C, Yu H, Wang J, Liu Z, Dasgupta PS, Basu S. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells. Proc Natl Acad Sci U S A 108:20730-20735, 2011.
- Shome S, Rana T, Ganguly S, Basu B, Chaki Choudhury S, Sarkar C, Chakroborty D, Dasgupta PS, Basu S. Dopamine regulates angiogenesis in normal dermal wound tissues. PLoS One 6:e25215, 2011.
- Ganguly S, Basu B, Shome S, Jadhav T, Roy S, Majumdar J, Dasgupta PS, Basu S. Dopamine, by acting through its D2 receptor, inhibits insulin-like growth factor-I (IGF-I) - induced gastric cancer cell proliferation via up-regulation of Krüppel-like factor 4 through down-regulation of IGF-IR and AKT phosphorylation. Am J Pathol 177:2701-2707, 2010.