Kalpana Ghoshal, PhD
The long-term goal of my lab is to understand the role of microRNAs and DNA methylation machinery in hepatocellular cancer (HCC), the most prevalent liver cancer. Our research focuses on gaining mechanistic insight on the molecular basis of HCC that could identify novel biomarkers for diagnosis/prognosis of the disease, and developing agents for prevention and therapy of liver cancer in pre-clinical models. Our study could be translated to human HCC patients in collaboration with oncologists at The Ohio State University Comprehensive Cancer Center.
1. 9R01CA193244-05A1 (PI: Ghoshal Kalpana) 4/1/10-11/30/2019 NCI Title: Role of microRNA-122 in hepatocarcinogenesis using conditional knockout mice.
2. 5R01CA086978-12 (MPI: Jacob Samson T. and Ghoshal Kalpana) 1/1/08-12/31/2018 NCI Title: Molecular mechanism of diet-induced carcinogenesis
Academic and Medical Appointments
2011-Present Associate Professor, Dept of Pathology, The Ohio State University, Columbus, OH
2011-Present Adjunct Associate Professor, Dept of Biological Chemistry & Pharmacology, The Ohio State University, Columbus, OH.
2010 Research Associate Professor, Dept of Molecular & Cellular Biochemistry, The Ohio State University, Columbus, OH
1996-2007 Research Scientist, Dept of Molecular & Cellular Biochem., The Ohio State University, Columbus, OH
1993-1996 Research Instructor, Dept. of Pharmacology and Molecular Biology, Rosalind Franklin University, The Chicago Medical School, North Chicago, IL
Education and Training
1988-1990 Post-doctoral Fellow, Dept. of Microbiology & Immunology, Chicago Medical School, North Chicago, IL
1982-1988 Ph.D. (Biochemistry), Dept. of Biochemistry, Calcutta University, Koltaka, India
1979-1981 M.Sc. (Biochemistry), Dept. of Biochemistry, Calcutta University, Koltaka, India
1974-1978 B.Sc. (Chemistry Honours, Physics, Math), Calcutta University, Koltaka, India