Department of Pathology

José J. Otero, MD, PhD

Associate Professor

Jose J. Otero, MD, PhD




Email Dr. Otero

Office Location:

4169 Graves Hall

Mailing Address:

4169 Graves Hall
333 W 10th Avenue
Columbus, OH 43210


I am an attending Neuropathologist at Wexner Medical Center and associate attending physician at The James Cancer Center. These duties include surgical neuropathology and autopsy neuropathology. I also receive consultations from community pathologists principally regarding surgical neuropathology but am also available to interpret neuromuscular and peripheral nerve pathology.

Board Certifications

American Board of Pathology, Anatomic Pathology

American Board of Pathology, Neuropathology

Academic and Medical Appointments

Associate Professor (Tenure Track), The Ohio State University College of Medicine, Department of Pathology

Attending Physician at The Ohio State University Wexner Medical Center and Associate Attending The James Cancer Hospital, Department of Pathology, Division of Neuropathology

Associate Director, Neuropathology Division, The Ohio State University College of Medicine and Wexner Medical Center

Principal Investigator, Developmental Neuropathology Laboratory at The Ohio State University College of Medicine, Division of Neuropathology, Department of Pathology

Member of The Ohio State University Wexner Medical Center, Center for Regenerative Medicine and Cell-Based Therapies and the OSU-James Comprehensive Cancer Center

Member of The Ohio State University Center for Latin American Studies

Adjunct Assistant Professor, The Ohio State University College of Medicine, Department of Neuroscience

Education and Training

2009-2012 Clinical Fellow, California Institute of Regenerative Medicine University of California, San Francisco

2006-2012 Molecular Medicine Fellowship, University of California, San Francisco

2008-2010 Neuropathology Fellowship, University of California, San Francisco, Department of Pathology, Neuropathology Division

2006-2008 Anatomic Pathology, University of California, San Francisco, Department of Pathology

2006 Doctor of Medicine, Northwestern University Feinberg School of Medicine

Selected Publications

Search in PubMed

Book Chapters:


  • Czeisler, C., Silva, T.M., Fair, S., Liu, J., Tupal, S., Kaya, b., Cowgill, A., Mahajan, S., Silva, P., Wang, Y., Blisset, A., Goksel, M., Brniger, J., Zhang, N., Fernandes-Junior, S., Catacutan, F., Alves, M., Nelson, R., Sundaresean, V., Rekling, J., Takakura, A., Moreira, T., Otero, J. The role of PHOX2B-derived astrocytes in chemosensory control of breathing and sleep hoemeostasis. Journal of Physiology, 2019, in press.
  • Alves, M., Goksel, M., Kaya, B., Gygli, P., Mustafa, H., Otero, J.CA, and Czeisler, C.CA, CCNA2 Ablation in Aged Mice Results in Abnormal rRNA Granule Accumulation in Hippocampus. American Journal of Pathology, in press.
  • Mei-Ling Liu, J., Fair, S.R., Kaya, B., Zuniga, J.N., Mostafa, H., Alves, M.J., Stephens, J.A., Jones, M., Aslan, M.T., Czeisler, C., Otero, J., Development of a Novel FIJI-Based Method to Investigate Neuronal Circuitry in Neonatal Mice. Dev Neurobiol. 2018 Nov;78(11):1146-1167.
  • Nabar, G., Mahajan, K., Calhoun, M., Duong, A., Souva, M., Xu, J., Czeisler, C., Puduvalli, V., Otero, J., Wysolouzil, B., Winter., J.CA, Micelle-templated, poly (lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery. International journal of Nano medicine, in press.
  • Otero, JJ.CA Neural Regeneration a Century after Ramón y Cajal’s Decree. American Journal of Pathology, in press.
  • Gallego-Perez, D., Pal, D., Subhadip, G., Malkox, V., Gnyawali, S., Ahmed, N., Chang, L., Sinha, M., Steen, E., Khanna, S., Rink, C., Otero, J.J., Lee, L.J., Sen, C. Skin transfection-activated reprogramming promotes in situ tissue repair. Nature Nanotechnology, 2017 Oct;12(10):974-979.
  • Short, A., Czeisler, C., Stocker, B., Cole, S., Otero, J.J.CA, Winter, J.CA Imaging Cell-Matrix Interactions in Three-Dimensional Collagen Culture Systems (2017) Macromolecular Bioscience, 17 (6) doi: 10.1002/mabi.201600478
  • Kaya, B., Goceri, E., Gygli, P., Czeisler, C., Gurcan, M.CA, Otero, J.J.CA Objective quantification of PTBP1 as a biomarker to identify recurrent glioma. PLOS-One, 2017 Mar 10;12(3):e0170991. doi: 10.1371/journal.pone.0170991. eCollection 2017.
  • Goceri, E., Kaya, B., Elder, B., Puduvalli, V., Otero, J.J.CA, Gurcan, M.CA Quantitative Validation of Anti-PTBP1 Antibody for Diagnostic Neuropathology Use: Image Analysis Approach. International Journal of Numerical Methods in Biomedical Engineering 2017 Nov;33(11). doi: 10.1002/cnm.2862. Epub 2017 Feb 10.
  • Ware, K., Feinstein, D., Rubinstein, I., Buttala, P., Otero, J., Hebert, L., Wang, T., Ivanova, A., Chaudhary, S., Hemminger, J., Brodsky, S. The Severity of Intracranial Hemorrhages Measured by Free Hemoglobin in the Brain Depends on the Anticoagulant Class: Experimental Data Stroke Res Treat. 2017; 2017: 6516401.
  • Czeisler C, Short A.M., Nelson T, Gygli P, Ortiz C, Catacutan FP, Lannutti J, Winter J, Otero J.J.CA. Surface Topography During Neural Stem Cell Differentiation Regulates Cell Migration and Cell Morphology. Journal of Comparative Neurology (2016): 524: 3485-3502.
  • Abas, F., Gokozan, H., Goksel, B., Otero, J.J.CA, Gurcan, M.CA Intraoperative neuropathology of glioma recurrence: cell detection and classification. SPIE 9791, Medical Imaging 2016: Digital Pathology, 979109 (23 March 2016)
  • Geng, F., Cheng, X., Wu, X., Yoo J., Cheng, C., Guo, J., Mo, X., Ru, P., Hurwitz, B., Kim, S., Otero, J., Puduvalli, V., Lefai, E., Ma, J., Nakano, I., Horbinski, C., Kaur, B., Chakravarti, A., Guo, D. Inhibition of SOAT1 suppresses glioblastoma growth by blocking SREBP-1 mediated lipogenesis. Clinical Cancer Research (2016) 22: 5337-5348.
  • Wang, J., Hong, C., Otero, J., Puduvalli, V., Elder, B. Genetic Characterization of a Multifocal Ganglioglioma Originating Within the Spinal Cord World neurosurgery, 2016, 608.
  • Gygli, P., Chang, J., Gokozan, H., Catacutan, F., Schmidt, T., Kaya, B., Goksel, M., Baig, F., Chen, S., Griveau, A., Michowski, W., Wong, M., Kamalakannan, P., Sicinski, P., Nelson, R., Czeisler, C., Otero, J.J.CA Cyclin A2 promotes DNA repair in the brain during both development and aging. Aging (2016) 8: 1540-1570.
  • Moreira, T.CA, Takakura, A., Czeisler, C., Otero, J.J. Respiratory and autonomic dysfunction in congenital central hypoventilation syndrome. Journal of Neurophysiology (2016) 116:742-752.
  • Gallego-Perez, D.*, Otero, J.*CA, Czeisler, C., Ma, J., Ortiz, C., Gygli, P., Catacutan, F., Gokozan, H., Cowgill, A., Sherwood, T., Ghatak, S., Malkoc, V., Zhao, X., Liao, W., Gnyawali, S., Wang, X., Adler, A., Leong, K., Wulff, B., Wilgus, T., Askwith, C., Khanna, S., Rink, C., Sen, C. CA, Lee CA. Deterministic Transfection Drives Efficient Nonviral Reprogramming and Uncovers Reprogramming Barriers. Nanomedicine (2016) 12: 399-409.