Department of Pathology

Thomas W. Prior, PhD


Thomas Prior, PhD




Email Dr. Prior

Office Location:

125 Hamilton Hall, Room D525

Mailing Address:

129 Hamilton Hall
1645 Neil Ave
Columbus, OH 43210


I have a longstanding research interest in the genetics of neuromuscular disorders, specifically in clinical applications and mutation detection. I have been most recently involved in the genetic disorder, spinal muscular atrophy (SMA). My laboratory developed the first SMA carrier test and I have been involved in both population carrier and newborn screening projects for SMA. I have also been active in determining the role of the SMN2 gene and other gene modifiers in effecting the disease phenotype and the identification of new types of mutations in the spinal muscular atrophy gene and their effect on the disease severity. The Laboratory has also been active in several SMA clinical trials. Over the years the Molecular Pathology Laboratory has also been involved in several research projects and clinical trials including: Muscular Dystrophy Cooperative Research Center (funded by the NIH), several projects funded by the Muscular Dystrophy Association, Clinical Trials for Pediatric Spinal Muscular Atrophy Project (funded by the NIH), Incidence and Molecular Screening for Hereditary Cancer (funded by the NIH), and Project Cure: SMN2 Copy Number Assay (funded by the Families of SMA). My laboratory performs a major teaching function at The Ohio State University Medical Center. Pathology residents, medical students, genetic post-doctoral fellows, graduate students and high school students perform rotations through the laboratory every year. I have also been the advisor of 6 PhD graduate students and have served on many graduate student committees. In 1992 we (along with Dr. Arthur Burghes and Dr. Paul Fuerst) established the first graduate class in Human Molecular Genetics at The Ohio State University.

Board Certifications

2011 10 year recertification, American Board of Medical Genetics-Subspecialty Clinical Molecular Genetics

Academic and Medical Appointments

2000-Present Professor, Director of Division of Molecular Pathology, Department of Pathology, The Ohio State University, Columbus Ohio.

Education and Training

1988-1989Postdoctoral Fellow, Dept. of Laboratory Medicine, University of North Carolina and North Carolina Memorial Hospital, Chapel Hill, North Carolina.

1983-1988Ph.D., Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia.

1978-1981M.S., Upstate Medical Center, Syracuse, New York.

1974-1978 B.A., Ohio Wesleyan University, Delaware, Ohio.

Selected Publications

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