Department of Pathology

Konstantin Shilo, MD

Associate Professor

Konstantin Shilo, MD

Phone:

614-293-5905

E-mail:

Email Dr. Shilo

Office Location:

E412 Doan Hall

Mailing Address:

E412 Doan Hall
410 West 10th Ave
Columbus, OH 43210

Biosketch

As a thoracic pathologist my interests in tumor biology are related to studies of protein expression. Tissue proteins represent a final functional element of gene expression, and as such are important targets for diagnosis, prognostication and treatment. I have studied and developed expertise in tumor protein expression profiling utilizing tissue microarrays. In recent collaborative projects including interdisciplinary teams, we identified further evidence that gene methylation and tumor microenvironment play an important role in aggressiveness and metastasis. In a study of protein arginine methyltransferase-5 (PRMT5), a chromatin-modifying enzyme capable of methylating histone and non-histone proteins, we showed that PRMT5 plays an important role in lung tumorigenesis and its cellular localization correlates with tumor grade reflecting its functional dichotomy in cellular compartments. Targeted therapies have revolutionized lung cancer treatments in recent years; however, frequencies of targetable mutations in non-small cell lung carcinoma (NSCLC) vary among patient populations. Employing novel sequencing techniques we investigated molecular profile of a large cohort of patients of African American ancestry and showed that it may not be significantly different from European/white background for the presence of somatic driver mutations in NSCLC suggesting that a comprehensive genotyping approach could identify targetable alterations with potential impact on treatment in that population. My research interests in the field of interstitial lung diseases (ILD) are guided by the clinical needs of a large university center. Collaborative efforts include projects evaluating lung toxicity in the setting of solid organ transplantation as well as in evaluation of lung toxicity in genetically modified viral infection and mechanisms of acute lung injury.

Board Certifications

2003 Anatomic and Clinical Pathology, American Board of Pathology

Academic and Medical Appointments

2010-Present Director, Thoracic Pathology Division, Department of Pathology, The Ohio State University, Columbus, OH

2004-2009 Pathologist, Department of Pulmonary & Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC

Education and Training

2003-2004 Fellowship, Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC

1998-2003 Resident, Anatomical & Clinical Pathology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH

1982-1998 M.D., St. Petersburg Pediatric Medical Institute, Russia

Selected Publications

Search in PubMed