Department of Pathology

Jian Zhu, PhD

Associate Professor

Jian Zhu, PhD

Phone:

614-293-4543

E-mail:

Email Dr. Zhu

Office Location:

119 Hamilton Hall

Mailing Address:

119 Hamilton Hall
1645 Neil Ave
Columbus, OH 43210

Dr. Zhu's Lab

Biosketch

Our lab studies the epigenetic aspects in viral infections and antiviral immune responses. We work at the interface of virology, immunology, genetics, cellular and molecular biology. We will identify novel epigenetic regulators that control viral persistence and antiviral responses, particularly for HIV and herpesviruses, by using modern functional genomic (RNAi, CRISPR/Cas9) and quantitative proteomic (MS, PLATO) approaches. We will further dissect the mechanistic functions of these key epigenetic regulators using classic cell and/or animal models of viral infections. Newly developed small-molecule compounds targeting epigenetic regulators will be also investigated as the next-generation antiviral reagents and/or immune modulators.

Areas of Expertise:

  • Epigenetics of viral persistence and immune response
  • Chemical inhibition of epigenetics as novel therapies
  • Systematic biology approaches for gene discovery
  • AIDS associated malignancies and pathogenesis

Grants

Title: Investigation of Latency Promoting Genes (LPGs) in HIV Oral Reservoir Cells

Role: Principal-Investigator

Sponsor: National Institutes of Health

Dates: 8/01/15-5/31/20


Title: Role of FACT Proteins in Regulating HIV Transcription and Latency

Role: Principal-Investigator

Sponsor: National Institutes of Health

Dates: 9/15/15-8/31/20


Title: Cooperation of BRD4 and Tat Associated Proteins in HIV Transcription and Latency

Role: Principal-Investigator

Sponsor: National Institutes of Health

Dates: 9/01/16-8/31/19

Academic and Medical Appointments

2018-Present Associate Professor (with Tenure), Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH

2013-2018 Assistant Professor, Department of Microbiology & Immunology, University of Rochester Medical Center, Rochester, NY

Education and Training

2009-2013 Postdoc, Brigham and Women’s Hospital at Harvard Medical School

2004-2009 PhD, Johns Hopkins University School of Medicine

2002-2004 MS, University of Nebraska Medical Center

1996-2000 BS, Peking University Health Science Center

Selected Publications

Search in PubMed