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Traci Wilgus, PhD

Associate Professor

Traci Wilgus, PhD

Phone:

614-366-8526

E-mail:

Email Dr. Wilgus

Mailing Address:

M364B Starling Loving Hall
320 W. 10th Ave
Columbus, OH 43210

Biosketch

Our research focuses on skin biology and cutaneous pathology. Much of our work revolves around understanding how pro-inflammatory and pro-angiogenic regulatory pathways contribute to skin cancer development, wound healing, and scar formation Our lab also uses a model of fetal wound healing to identify novel pro- and anti-fibrotic signaling pathways and to understand the molecular mechanisms leading to regeneration and scarless healing in fetal skin.

Grants

Title: Understanding the role of VEGF in scar formation

Role: Principal Investigator

Sponsor: NIH/NIAMS

Dates: 07/01/2021 - 06/30/2023

The primary goal of this project is to understand whether VEGF can directly stimulate fibroblasts to promote scar formation in the skin.

Academic and Medical Appointments

Associate Professor, Department of Pathology, The Ohio State University, Columbus Ohio.

Education and Training

2003-2006 Postdoctoral Fellow, Department of Surgery, Loyola University Chicago Medical Center, Maywood, IL

2002-2003 Postdoctoral Fellow, Department of Pathology, The Ohio State University, Columbus, OH

1998-2001 Ph.D., Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH

1995-1998 B.S., Microbiology, The Ohio State University, Columbus, OH

Selected Publications

Search in PubMed

  • S Ud-Din, TA Wilgus, DD McGeorge, and A Bayat. 2021. Pre-emptive priming of human skin improves cutaneous scarring and is superior to immediate and delayed topical anti-scarring treatment post-wounding: A double-blind randomized placebo-controlled trial. Pharmaceutics 13(4): 510.
  • TA Wilgus. 2021. A murine incisional fetal wound healing model to study scarless and fibrotic skin repair. Methods Mol Biol 2193: 13-21.
  • LA DiPietro, TA Wilgus, TJ Koh. Macrophages in healing wounds: Paradoxes and paradigms. Int J Mol Sci 22(2): 950.
  • TA Wilgus, S Ud-Din, A Bayat. 2020. A review of the evidence for and against a role for mast cells in cutaneous scarring and fibrosis. Int J Mol Sci 21(24): 9673.
  • SC Gnyawali, M Sinha, MS El Masry, BC Wulff, S Ghatak, F Soto-Gonzalez, TA Wilgus, S Roy, and CK Sen. 2020. High Resolution ultrasound imaging for repeated measure of wound tissue morphometry, biomechanics, and hemodynamics under fetal, adult and diabetic conditions. PLoS One 15(11): e0241831.
  • TA Wilgus. 2020. Inflammation as an orchestrator of cutaneous scar formation: A review of the literature. Plast Aesthet Res 7(54) 1-18.
  • S Ud-Din, TA Wilgus, and A Bayat. 2020. Mast cells in skin scarring: A review of animal and human research. Front Immunol 11:552205.
  • BN Blackstone, TA Wilgus, S Roy, BC Wulff, and HM Powell. 2020. Skin biomechanics and miRNA expression following chronic UVB Irradiation. Adv Wound Care 9(3): 79-89.
  • TA Wilgus. 2019. Vascular endothelial growth factor and cutaneous scarring. Adv Wound Care 8(12): 671-678.
  • BC Wulff, NK Pappa, and TA Wilgus. 2019. Interleukin-33 encourages scar formation in murine fetal skin wounds. Wound Repair Regen 27(1) 19-28.
  • TA Wilgus. 2018. Alerting the body to tissue injury: The role of alarmins and DAMPs in cutaneous wound healing. Curr Pathobiol Rep 6(1): 55-60.
  • TA Wilgus. 2017. New mechanisms of ECM production during wound healing: A role for parathyroid hormone 2 receptor signaling. J Invest Dermatol 137(8): 1617-1619.
  • DM DeBruler, BN Blackstone, ME Baumann, KL McFarland, BC Wulff, TA Wilgus, JK Bailey, DM Supp, and HM Powell. 2017. Inflammatory responses, matrix remodeling, and re-epithelialization after fractional CO2 laser treatment of scars. Lasers Surg Med 49(7): 675-685.
  • D Gallego-Perez, JJ Otero, C Czeisler, J Ma, C Ortiz, P Gygli, FP Catacutan, HN Gokozan, A Cowgill, T Sherwood, S Ghatak, V Malkoc, X Zhao, WC Liao, S Gnyawali, X Wang, AF Adler, K Leong, B Wulff, TA Wilgus, C Askwith, S Khanna, C Rink, CK Sen, LJ Lee. 2016. Deterministic transfection drives efficient nonvital reprogramming and uncovers reprogramming barriers. Nanomedicine 12(2): 399-409.
  • L Chen, ME Schrementi, MJ Ranzer, TA Wilgus, LA DiPietro. 2014. Blockade of mast cell activation reduces cutaneous scar formation. PLoS One 9(1): e85226.
  • KE Johnson, BC Wulff, TM Oberyszyn, and TA Wilgus. 2013. Ultraviolet light exposure stimulates HMGB1 release by keratinocytes. Arch Dermatol Res 305(9): 805-815.
  • BC Wulff and TA Wilgus. 2013. Mast cell activity in the healing wound: More than meets the eye? Exp Dermatol 22(8): 507-510.
  • JC McDaniel, S Roy, and TA Wilgus. 2013. Neutrophil Activity in Chronic Venous Leg Ulcers – A Target for Therapy? Wound Repair Regen 21(3): 339-351.
  • AD Dardenne, BC Wulff, and TA Wilgus. 2013. The alarmin HMGB-1 influences healing outcomes in fetal skin wounds. Wound Repair Regen 21(2): 282-291.
  • BC Wulff and TA Wilgus. 2013. Examining the role of mast cells in fetal wound healing using cultured cells in vitro. Methods Mol Biol 1037: 495-506.
  • BC Wulff, L Yu, AE Parent, and TA Wilgus. 2013. Novel differences in the expression of inflammation-associated genes between mid- and late-gestational dermal fibroblasts. Wound Repair Regen 21(1): 103-112.
  • TA Wilgus and LA DiPietro. 2012. Complex roles for VEGF in dermal wound healing. J Invest Dermatol 132(2): 493-4.
  • BC Wulff, AE Parent, MA Meleski, LA DiPietro, ME Schrementi, and TA Wilgus. 2012. Mast cells contribute to scar formation during fetal wound healing. J Invest Dermatol 132(2): 458-65.