HISTORY:
                       Patient is a 63 year old female with 48 year history of smoking, stroke, TIA (transient ischemic attack), and neoplasm of right renal pelvis. Previous CT pelvis w/ contrast revealed a 5x8 mm filling defect in the right renal pelvis, with a linear filling defect extending from this area into the lower pole calyx. Cystourethroscopy w/ right urethral catheterization and right ureter stent insertion was performed. Excision of paracaval, hilar, interaortocaval lymph nodes, and right nephrectomy with total ureterectomy was performed on follow up.
                             
                 
                 
                    
GROSS:
                       The kidney is opened to reveal multifocal areas of papillary, granular tan tissue within the renal pelvis and major calyces.  These areas range in size from 0.2 x 0.2 cm to 2.0 x 1.0 cm. The peripelvic fat, renal hilar fat, perinephric fat, and kidney parenchyma are uninvolved
                            
                     The remaining kidney parenchyma consists of a tan-white ill-defined area within the superior pole of the parenchyma that measures 0.5 x 0.3 x 0.3 cm.
                        
                     The ureter is opened to reveal a granular and minimally edematous cut surface to tan-brown and depressed cut surface
                        
                     No evidence of neoplasia found in lymph nodes
                        
                    
                
                
                         
                        
                       
                        
                      
                        
                       
                        
                        
               
                                  
                
                    
                 
                            What is the most likely diagnosis?
                            
                        
                             - Renal cell carcinoma with tubular differentiation
 
                             - Ductal cell carcinoma 
 
                             - Urothelial carcinoma with intratubular spread
 
                             - Nested variant of urothelial carcinoma 
 
                            
                          
                       
                         
                        
                         
                            
                         
                    Urothelial carcinoma with intratubular spread