Date of Presentation:7/22/2024

Attending pathologist: Anil Parwani, MD, PhD, MBA

Presented by: Sonali Pitale, MD

Organ:Bladder

HISTORY:

Male in his 80’s

History of Bladder Inflammation/Hematuria (outside case)

A radical cystoprostatectomy specimen

Post neo-adjuvant therapy

Bladder mass- A 4.5 x 3 cm dark red nodular area on the dome mucosa with yellow central necrotic area abutting the inked outer surface of the urinary bladder

GROSS:

Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue

What is the most likely diagnosis?

  1. Small cell neuroendocrine carcinoma
  2. Poorly differentiated urothelial carcinoma
  3. Lymphoepithelioma-like carcinoma
  4. Non-Hodgkin lymphoma
Small cell neuroendocrine carcinoma