Department of Clinical Laboratories

FISH Probes by Chromosome Number

1
...
  • CDKN2C/CKS1B
  • PBX1/TCF3
  • ABL2 ba
2
...
  • NMYC/2 centromere
  • ALK ba
  • REL/DIRC
  • IGK ba
3
...
  • MECOM ba
  • BCL6 ba
4
...
  • 4 centromere
  • IGH/FGFR3
  • PDGFRA ba
5
...
  • EGR1/5p15.2
  • PDGFRB ba
  • CSF1R/5p15.2
6
...
  • DEK/NUP214
  • IGH/CCND3
  • SEC63/MYB
7
...
  • 7 centromere
  • D7S486
  • CUX1/CUL1
  • TRB ba
8
...
  • 8 centromere
  • FGFR1 ba
  • MYC ba
  • IGH/MYC/8 centromere
  • RUNX1T1/ RUNX1
9
...
  • 9 centromere
  • JAK2 ba
  • CDKN2A
  • BCR/ABL1
  • ASS1
  • ABL1 ba
  • DEK/NUP214
10
...
  • 10 centromere
11
...
  • NUP98 ba
  • IGH/CCND1
  • BIRC3/MALT1
  • ATM
  • KMT2A ba
12
...
  • 12 centromere
  • ETV6 ba
  • ETV6/RUNX1
13
...
  • FOXO1 ba
  • RB1/LAMP1
  • D13S319/LAMP1
14
...
  • TCL1 ba
  • IGH ba
  • IGH/FGFR3
  • IGH/CCND3
  • IGH/MYC/8 centromere
  • IGH/CCND1
  • IGH/MAF
  • IGH/BCL2
  • IGH/MAFB
15
...
  • 15 centromere
  • PML/RARA
16
...
  • MYH11/CBFB
  • CBFB ba
  • IGH/MAF
17
...
  • 17 centromere
  • TP53/17 centromere
  • PML/RARA
  • RARA ba
18
...
  • IGH/BCL2
  • BIRC3/MALT1
19
...
  • BCL3 ba
  • PBX1/TCF3
20
...
  • D20S108
  • IGH/MAFB
21
...
  • RUNX1 ba
  • RUNX1T1/RUNX1
  • ETV6/RUNX1
22
...
  • BCR/ABL1
  • EWSR1 ba
...
  • XY
  • CRLF2 ba
  • P2RY8 ba

FISH Probes by Disease

AML
  • MECOM
  • EGR1
  • DEK/NUP214
  • D7S486
  • RUNX1T1/RUNX1
  • NUP98
  • KMT2A
  • PML/RARA
  • CBFB
  • TP53
B-Cell ALL
  • CRLF2
  • P2RY8
  • PBX1/TCF3
  • ABL2
  • 4 & 10 centromere
  • PDGFRB
  • MYC
  • JAK2
  • CDKN2A
  • BCR/ABL1
  • ABL1
  • KMT2A
  • ETV6/RUNX1
MDS
  • CSF1R/5p15.2
  • EGR1/5p15.2
  • 7 centromere /D7S486
  • 8 centromere
  • TP53
  • D20S108
MPD
  • PDGFRA
  • PDGFRB
  • FGFR1
  • JAK2
  • BCR/ABL1
Eosinophilia AEL / CEL
  • PDGFRA
  • PDGFRB
  • FGFR1
  • ETV6
CLL/SLL
  • ATM
  • TP53
  • 12 centromere
  • D13S319
  • LAMP1
  • MYC
  • CDKN2A
  • IGH
NHL B-Cell
  • BCL6
  • MYC
  • IGH/BCL2
NHL T-Cell
  • TRB
  • TCL1
Myeloma
  • CDKN2C/CKS1B
  • 7,9,15 centromeres
  • ATM
  • RB1/LAMP1
  • TP53
  • IGH/CCND1
  • IGH
  • IGH/FGFR3
  • IGH/MAF
  • IGH/MAFB
  • IGH/CCND3
Other Lymphomas
  • MYC
  • BIRC3/MALT1
  • IGH/MYC
  • IGH/CCND1
  • IGH/BCL2
  • IGH or IGK for variants