Date of Presentation:11/16/2021

Attending pathologist: Anil Parwani, MD, PhD, MBA

Presented by: Saba Shafi, MD

Prepared by: Saba Shafi, MD



A 59-year-old male with a history of elevated PSA, started above 4 and rising, most recent being 10.7 ng/ml. MRI prostate showed prostatomegaly with mild BPH changes with a PI-RADS 4 nodule seen in the left anterior peripheral zone at the apex. A prostate biopsy was performed.


What is the most likely diagnosis?

  1. Prostatic adenocarcinoma, Gleason grade 4+4 (cribriform pattern)
  2. Prostatic intraepithelial neoplasm (PIN), high grade
  3. Clear cell cribriform hyperplasia of prostate
  4. Basal cell hyperplasia of prostate
Clear cell cribriform hyperplasia of prostate