Anatomical Pathology Interesting Case Conference

Date of Presentation:11/16/2021

Attending pathologist: Anil Parwani, MD, PhD, MBA

Presented by: Saba Shafi, MD

Prepared by: Saba Shafi, MD

Organ:Prostate

HISTORY:

A 59-year-old male with a history of elevated PSA, started above 4 and rising, most recent being 10.7 ng/ml. MRI prostate showed prostatomegaly with mild BPH changes with a PI-RADS 4 nodule seen in the left anterior peripheral zone at the apex. A prostate biopsy was performed.

GROSS:

Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue

What is the most likely diagnosis?

  1. Prostatic adenocarcinoma, Gleason grade 4+4 (cribriform pattern)
  2. Prostatic intraepithelial neoplasm (PIN), high grade
  3. Clear cell cribriform hyperplasia of prostate
  4. Basal cell hyperplasia of prostate
Clear cell cribriform hyperplasia of prostate

CASE SUMMARY