OSU Department of Pathology

Anatomical Pathology Interesting Case Conference

Date of Presentation:2/25/2021

Attending pathologist: Anil Parwani, MD, PhD

Presented by: Bindu Challa, MD

Prepared by: Bindu Challa, MD

Organ:Bladder

HISTORY:

A male in his 60s presented with gross hematuria. Cystourethroscopy revealed a bladder tumor at the dome, posterior wall and left lateral wall. He was followed up with transurethral resection of bladder tumor (TURBT).

GROSS:

The specimen is designated "large volume multifocal bladder tumors (solid and papillary)" and consists of an aggregate of irregularly-shaped, tan/pink soft tissue fragments with cautery present which measures 6.1 x 5.6 x 1.1 cm.

Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue

What is the most likely diagnosis?

  1. Lymphoma
  2. Urothelial carcinoma with lymphoepithelioma-like features
  3. Paraganglioma of urinary bladder
  4. Urothelial carcinoma with small cell/neuroendocrine features and conventional features
  5. Urothelial carcinoma with large cell/neuroendocrine features
Urothelial carcinoma with small cell/neuroendocrine features and conventional features

Case Summary