Date of Presentation:5/07/2021

Attending pathologist: Anil Parwani, MD, PhD, MBA

Presented by: Bindu Challa, MBBS

Prepared by: Bindu Challa, MBBS

Organ:Kidney

HISTORY:

A male patient in his 70s presents with non-radiating, sharp, right-sided lumbar pain. Computed tomography abdomen and pelvis showed mildly enhancing lesion in upper pole of right kidney measuring 4.6 cm x 3.1 cm and Computed tomography chest showed several osteolytic lesions and T10 compression fracture. He was followed up with a biopsy of renal mass.

GROSS:

The specimen is designated "right renal mass" and consists of four tan-red soft tissue cores ranging from 0.3-0.9 cm in length x 0.1 cm in diameter.

Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Table describing IHC workups on renal mass

CDX2, SOX10, Ck20, PAX8, p63, TTF1, CAIX, AE1/AE3, CK7, Melan A stains were also done and read as negative.

What is the most likely diagnosis?

  1. Renal cell carcinoma with sarcomatoid features
  2. Anastomosing hemangioma
  3. Hemagioendothelioma
  4. Primary Renal Angiosarcoma
  5. Epithelioid angiomyolipoma
Primary Renal Angiosarcoma

CASE SUMMARY