Date of Presentation:5/21/2021

Attending pathologist: Anil Parwani, MD, PhD, MBA

Presented by: Jennifer Ziebell, MD

Prepared by: Jennifer Ziebell, MD



57 year old male with a past medical history of low testosterone (on supplementation) who presented with increased nocturia and weaker urinary stream that developed over the past two months. PSA increased from 2.38 ng/mL to 4.45 ng/mL over those two months. The patient decided to proceed with a prostate biopsy.


What is the most likely diagnosis?

  1. Prostatic adenocarcinoma, Gleason score 4+3=7
  2. High grade prostatic intraepithelial neoplasia (HGPIN)
  3. Intraductal carcinoma of the prostate
  4. Prostatic adenocarcinoma, Gleason score 3+4=7
Intraductal carcinoma of the prostate