Department of Pathology

Division of
Molecular Pathology

Welcome to the Division of Molecular Pathology

Our Division, based in the James Cancer Hospital and OSUWMC Department of Pathology, provides clinical molecular diagnostics for a wide range of cancers and other heritable disorders. Our mission is to provide cutting edge, clinically responsible and cost-effective diagnostics for the patients of Ohio and beyond. Testing is performed for cancer conditions, cardiovascular risk and for inherited genetic disorders.

MOLECULAR HIGHLIGHTS:

Molecular Pathology is a medical specialty that seeks to integrate microscopic findings with the genetic changes associated with diseases such as cancer and inflammatory conditions. Goals of this work in cancer patients include more precise diagnostic classification, improved early detection of cancer and providing help in selecting therapies. Another important goal for Molecular Pathology in some cancers is more sensitive detection of low levels of disease to help guide when to continue or restart treatments to help lower the rates of relapse.

Our Clinical Laboratories: Leaders in Translational Research

  • International reference laboratory for monitoring and resistance testing for BTK inhibitors
  • Central laboratory for dozens of targeted therapy cancer trials in hematologic malignancies and solid tumors
  • A leader in diagnosis of neuromuscular disorders with participation in clinical trials and research initiatives for Spinal Muscular Atrophy
  • In collaboration with the OSU Department of Genetics, assay development for the NIH-sponsored Molecular Screening for Hereditary Cancer projects
  • Principal testing centers for the Ohio Colorectal Center Prevention Initiative
  • Advanced DNA sequencing methods: Ion Torrent and Illumina Platforms
  • Digital drop PCR
  • Computer-assisted Fluoresence Imaging for FISH
  • Custom gene sequencing panels
  • Integrated molecular cancer panels for mutations, translocation and MSI detection, and immunotherapy applications

Informatics & Molecular Diagnostics

The ongoing challenge of Molecular Diagnostics and Genomic Medicine is to rapidly integrate new knowledge about the function of genes into actionable clinical information to tailor patient treatments. This involves computer-assisted analysis of sequence data and new methods to display results of genetic tests in the medical record. The Bioinformatics group in our laboratories designs data pipelines and analysis tools to promote the diagnostic impact of our genomic testing.

dan jones

Dan Jones, MD, PhD

Division Director, Vice Chair

Professor

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Dr. zhao

Weiqiang Zhao, MD, PhD

Medical Director

Professor

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Dr. Avenarius

Matthew Avenarius, PhD

Director (Associate)

Assistant Professor

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Dr. Miller

Cecelia Miller, PhD

Director (Associate)

Assistant Professor

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Dr. ren

Rongqin Ren, MD, PhD

Director (Associate)

Assistant Professor

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