Division of Molecular Pathology | James Molecular Laboratory
Hematologic Neoplasms:
International reference laboratory for monitoring and resistance testing for BTK inhibitors
Identifying novel mechanisms of resistance to BTK inhibitors
Models of progression myeloid neoplasms
Improved genomic diagnosis of B-cell lymphoma
Developing algorithms to risk stratify patients with germline variants that may predispose to hematologic disorders
Genomics of Neuromuscular Disorders(Matt Avenarius):
SMA advanced sequencing assays (supported by a Muscular Dystrophy Association Idea Grant)
C9orf72/amyotrphic lateral sclerosis (ALS)
JML Bioinformatics Group:
Reporting tools for serial genomic monitoring of hematologic malignancies with NGS
Defining critical shifts in the viral microbiome for community surveillance activities
Reducing complexity in transcriptome RNAseq to limited signatures for routine diagnostic AI Deep Learning
Improved tools for MSI and fusion transcript detection from DNA-based NGS
Molecular Technology Development:
Developing a clinical trials companion diagnostic assay for T-DXd using quantitative digital imaging analysis for HER2 protein expression levels (Yan Hu)
Rapid DNA sequencing algorithms to speed therapy initiation in advanced and high-risk cancers
Improvement to digital droplet (dd) PCR methods for accurate rare event detection
