Anatomical Pathology Interesting Case Conference

Date of Presentation:2/18/2021

Attending pathologist: Anil Parwani, MD, PhD

Presented by: Bindu Challa, MD

Prepared by: Bindu Challa, MD

Organ:Prostate

HISTORY:

A male in his 60s presented with urinary obstructive symptoms, was found to have abnormal digital rectal examination and prostate specific antigen (PSA) level was 1.51 ng/ml. Computed tomography (CT) Abdomen/Pelvis and cystourethroscopy showed no abnormalities.

GROSS:

Multiple tan core biopsy fragments of prostate ranging from 0.3 cm x 0.1 cm x 0.1 cm to 1.5 cm x 0.2 cm x 0.2 cm.

Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue

What is the most likely diagnosis?

  1. High grade prostate intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma
  2. Intraductal carcinoma of prostate and prostate adenocarcinoma
  3. High grade prostate intraepithelial neoplasia (HGPIN) and intraductal carcinoma of prostate
  4. High grade prostate intraepithelial neoplasia(HGPIN) and PIN-like carcinoma
  5. Clear cell cribriform hyperplasia and prostate adenocarcinoma
Intraductal carcinoma of prostate and prostate adenocarcinoma

CASE SUMMARY