Date of Presentation:8/27/2025

Attending pathologist: Anil Parwani, MD, PhD, MBA

Presented by: Akansha Deshwal, MD

Prepared by: Nishant Rangwani, BS, Briggs Ham BS, Gibson Hohberg, BS

Organ:Prostate

HISTORY:

A male in his 70’s, presented for urologic evaluation of hematospermia without gross hematuria. The significant genitourinary history included urinary hesitancy, microhematuria, and Benign Prostatic Hyperplasia. The family history revealed history of prostate cancer in father.

Urinalysis showed moderate amount of blood. Renal ultrasound showed non-specific prostatomegaly and no evidence of hydronephrosis or stones.

Cystoscopy revealed significant prostatic enlargement, right > left, bladder contained diverticula and no other lesions.

The PSA levels were 21.8 ng/mL. A TRUS biopsy was recommended.

GROSS:

The specimen is received as fourteen tan-pink cores, ranging from 0.5 cm to 1.8 cm in length.

Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue
Microscopic image possibly detecting cancerous areas in human tissue

What is the most likely diagnosis?

  1. Ductal Adenocarcinoma of the Prostate
  2. High-Grade Prostatic Intraepithelial Neoplasia
  3. Urothelial Carcinoma in situ
  4. Intraductal Carcinoma of the Prostate
Intraductal Carcinoma of the Prostate