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Sergey V. Brodsky, MD, PhD

Professor-Clinical

Sergey Brodsky, MD, PhD

Phone:

614-688-5831

E-mail:

Email Dr. Brodsky

Mailing Address:

4173 Graves Hall
333 W 10th Ave
Columbus, OH 43210

Biosketch

Dr. Brodsky graduated from North Ossetian State Medical Academy (Russia) in 1992 (MD). He obtained his PhD from the same medical school. After graduation, he stared his career as a researcher (see main topics below). In 2005-08 he completed residency in Anatomic Pathology (New York Medical College) and in 2008-09 he finished a fellowship in renal and transplant pathology at OSU. Dr. Brodsky is author/coauthor in more than 130 peer-reviewed publications and several book chapters. Currently his is working on an R01 grant from the NIH to study the mechanisms of anticoagulant-related nephropathy. His main topics of research are:

  1. Mechanisms of renal blood flow and vascular tone regulation. Regulation of renal function and renal blood flow in experimental congestive heart failure.
  2. Endothelial cell dysfunction in hypertension and diabetes mellitus. Mechanisms of endothelial cell injury, the role of nitric oxide. Role of endothelial cell dysfunction in acute kidney injury.
  3. Angiogenesis and mechanisms of its regulation. Developed novel model of kidney angiogenesis in vitro.
  4. Endothelial microparticles and their role in the pathogenesis of endothelial cell dysfunction and angiogenesis.
  5. Anticoagulation and kidney function. Novel syndrome was discovered in patients on warfarin therapy and acute kidney injury (warfarin related nephropathy), an animal model was created and the pathogenesis is being studied.
  6. Renal pathology in patients with medical kidney diseases or kidney transplantation. Developed novel dual stain (PAS-Trichrome), which is currently used in the renal pathology practice.

Board Certifications

2009 Anatomic Pathology, American Board of Pathology

Academic and Medical Appointments

2015-Present Associate Professor, Department of Pathology, The Ohio State University, Columbus, Ohio

2009-2015 Assistant Professor, Department of Pathology, The Ohio State University, Columbus, Ohio

2002-2005 Instructor and Assistant Professor, Department of Medicine, New York Medical College, Valhalla, NY

1999-2002 Research Scientist, Department of Medicine, State University of New York, Stony Brook, NY

1997-1999 Postdoctoral Research Scientist, Department of Physiology, Technion - Israel Institute of Technology, Haifa, Israel

1995-1996 Assistant professor, Department of Physiology, North Ossetian State Medical Academy , Russia

Education and Training

2008-2009 Fellow, Renal Pathology, The Ohio State University, Columbus, Ohio

2005-2008 Resident, Anatomic Pathology, New York Medical College at Westchester Medical Center, Valhalla, NY

1992-1995 Ph.D., North Ossetian State Medical Academy, Russia

1984-1992 M.D., North Ossetian State Medical Academy, Russia

Selected Publications

Search in PubMed

Books:

  • Infection-Related Glomerulonephritis. Brodsky SV, Nadasdy T. Contributions to Nephrology Editor: G.A. Herrera, 2011. 169:153-60.
  • Tubulointerstitial nephritis. Brodsky SV, Nadasdy T. Heptinstall's Pathology of the Kidney. Editors: Jennette, J.C., Olson, J.L., Schwartz, M.M., Silva, F.G. Lippincott Williams & Wilkins, 2013, 7th edition.

Publications:

  • Satoskar AA, Suleiman S, Ayoub I, Hemminger J, Parikh S, Brodsky SV, Bott C, Calomeni E, Nadasdy GM, Rovin B, Hebert L, Nadasdy T. Staphylococcus Infection-Associated GN - Spectrum of IgA Staining and Prevalence of ANCA in a Single-Center Cohort. Clin J Am Soc Nephrol. 2017 Jan 6;12(1):39-49. doi: 10.2215/CJN.05070516.
  • Brodsky SV, Hebert LA. Anticoagulant-Related Nephropathy: Is an AKI Elephant Hiding in Plain View? J Am Coll Cardiol. 2016 Nov 29;68(21):2284-2286. doi: 10.1016/j.jacc.2016.09.926.
  • Brodsky SV, Barth RF, Mo X, Yildiz V, Allenby P, Ivanov I, Moore S, Hitchcock CL, Smith S, Sachak T, Yao K, Ball M, Rosborough K, Olson Z, Kiehl M, Muni N, Virmani R. An obesity paradox: an inverse correlation between body mass index and atherosclerosis of the aorta. Cardiovasc Pathol. 2016 Sep 13;25(6):515-520.
  • Brodsky SV, Gruszecki AC, Fallon K, Pasquale-Styles MA, Shaddy S, Yildiz V, Long SK, MacDonell M, Brideau RL, Keane J, Allenby P, Ivanov I, Moore S, Smith SM, Sachak T, Ball M, Yao K, James I, Muni N, Barth RF. Morphometric data on severely and morbidly obese deceased, established on forensic and non-forensic autopsies. Virchows Arch. 2016 Oct;469(4):451-8.
  • Oghumu S, Nori U, Bracewell A, Zhang J, Bott C, Nadasdy GM, Brodsky SV, Pelletier R, Satoskar AR, Nadasdy T, Satoskar AA. Differential gene expression pattern in biopsies with renal allograft pyelonephritis and allograft rejection. Clin Transplant. 2016 Sep;30(9):1115-33. doi: 10.1111/ctr.12795.
  • Feinstein DL, Akpa BS, Ayee MA, Boullerne AI, Braun D, Brodsky SV, Gidalevitz D, Hauck Z, Kalinin S, Kowal K, Kuzmenko I, Lis K, Marangoni N, Martynowycz MW, Rubinstein I, van Breemen R, Ware K, Weinberg G. The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures. Ann N Y Acad Sci. 2016 May 31. doi: 10.1111/nyas.13085. [Epub ahead of print].
  • Ryan MS, Satoskar AA, Nadasdy GM, Brodsky SV, Hemminger JA, Nadasdy T. Phospholipase A2 receptor staining is absent in many kidney biopsies with early-stage membranous glomerulonephritis. Kidney Int. 2016 Jun;89(6):1402-3.
  • Hemminger J, Nadasdy G, Satoskar A, Brodsky SV, Nadasdy T. IgG Subclass Staining in Routine Renal Biopsy Material. Am J Surg Pathol. 2016 May;40(5):617-26.
  • Ware KM, Feinstein DL, Rubinstein I, Weinberg G, Rovin BH, Hebert L, Muni N, Cianciolo RE, Satoskar AA, Nadasdy T, Brodsky SV. Brodifacoum Induces Early Hemoglobinuria and Late Hematuria in Rats: Novel Rapid Biomarkers of Poisoning. Am J Nephrol. 2015 Jun 20;41(4-5):392-399.
  • Ware KM, Vance JC, Muni N, Hebert LA, Satoskar AA, Nadasdy G, Ivanov I, Nadasdy T, Rovin BH, Brodsky SV. Oral Warfarin and the Thrombin Inhibitor Dabigatran Increase Blood Pressure in Rats: Hidden Danger of Anticoagulants? Am J Hypertens. 2015 Feb;28(2):182-9.
  • Brodsky SV Anticoagulants and acute kidney injury: clinical and pathology considerations. Kidney Res Clin Pract. 2014 Dec;33(4):174-80
  • Qamri Z, Pelletier R, Foster J, Kumar S, Momani H, Ware K, Von Visger J, Satoskar A, Nadasdy T, Brodsky SV. Early posttransplant changes in circulating endothelial microparticles in patients with kidney transplantation. Transpl Immunol. 2014 Aug;31(2):60-4.
  • Chen W, Brodsky SV, Zhao W, Otterson GA, Villalona-Calero M, Satoskar AA, Hasan A, Pelletier R, Ivanov I, Ross P, Nadasdy T, Shilo K. Y-chromosome status identification suggests a recipient origin of posttransplant non-small cell lung carcinomas: chromogenic in situ hybridization analysis. Hum Pathol. 2014 May;45(5):1065-70.
  • Oghumu S, Bracewell A, Nori U, Maclean KH, Balada-Lasat JM, Brodsky S, Pelletier R, Henry M, Satoskar AR, Nadasdy T, Satoskar AA. Acute Pyelonephritis in Renal Allografts-A New Role for MicroRNAs? Transplantation. 2014 Mar 15;97(5):559-68.
  • Gaughan A, Wang J, Pelletier RP, Nadasdy T, Brodsky S, Roy S, Lodder M, Bobek D, Mofatt-Bruce S, Fairchild RL, Henry ML, Hadley GA. Key Role for CD4 T Cells During Mixed Antibody-Mediated Rejection of Renal Allografts. Am J Transplant. 2014 Feb;14(2):284-94
  • Ryan M, Ware K, Qamri Z, Satoskar A, Wu H, Nadasdy G, Rovin B, Hebert L, Nadasdy T, Brodsky SV. Warfarin-related nephropathy is the tip of the iceberg: direct thrombin inhibitor dabigatran induces glomerular hemorrhage with acute kidney injury in rats. Nephrol Dial Transplant. 2014 Dec;29(12):2228-34. doi: 10.1093/ndt/gft380. Epub 2013 Sep 5.
  • Roth RM, Benson D, Hebert LA, Bissell MG, Satoskar AA, Nadasdy T, Brodsky SV. Progressive renal light chain amyloidosis with the absence of detectable free monoclonal light chains after an autologous hematopoietic stem cell transplant for amyloid light chain amyloidosis. Arch Pathol Lab Med. 2013 Sep;137(9):1304-8
  • Ware K, Qamri Z, Ozcan A, Satoskar A, Nadasdy G, Rovin BH, Hebert LA, Nadasdy T, Brodsky SV. N-Acetylcysteine Ameliorates Acute Kidney Injury But Not Glomerular Hemorrhage In An Animal Model Of Warfarin Related Nephropathy. Am J Physiol Renal Physiol. 2013 Jun;304(12):F1421-7