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Aharon Freud, MD, PhD

Associate Professor

Aharon Freud, MD, PhD

Phone:

614-293-7904

E-mail:

Email Dr. Freud

Mailing Address:

892 Biomedical Research Tower
460 W. 12th Ave.
Columbus, OH 43210

Biosketch

Our laboratory studies the developmental biology and lymphomagenesis of human innate lymphoid cells (ILCs). ILCs comprise a diverse group of specialized lymphocytes that are involved in many aspects of physiology and pathophysiology including mucosal immunity, lymphoid neogenesis, cancer, allergy, and metabolism. ILCs are distinct from T and B lymphocytes in that ILCs do not rearrange their antigen-specific receptors. Our lab works with primary human tissue samples, such as blood, bone marrow, tonsils, spleen, and lymph nodes, to characterize novel ILC developmental intermediates that have been recently discovered. Common laboratory techniques employed include flow cytometry, cell sorting, in vitro culture, transplantation into immunodeficient mice, and molecular profiling & genetic manipulation. The ultimate goal of this work is to understand how ILCs develop normally and how such information can be used clinically to combat disease. Another major goal of this work is to understand how ILCs undergo malignant transformation.

Board Certifications

Hematopathology, American Board of Pathology

Anatomic and Clinical Pathology, American Board of Pathology

Academic and Medical Appointments

2013-Present Assistant Professor, Department of Pathology, The Ohio State University, Columbus Ohio.

Education and Training

2011-2013 Clinical Pathology Residency, Stanford University, Palo Alto, CA

2010-2011 Hematopathology Fellowship, Stanford University, Palo Alto, CA

2008-2010 Anatomic Pathology Residency, Stanford University, Palo Alto, CA

2000-2008 MD/PhD, MSTP, The Ohio State University, Columbus, OH

1996-2000 B.S., University of Wisconsin, Madison, WI

Selected Publications

Search in PubMed

  • Victor AR, Weigel C, Scoville SD, Chan WK, Chatman K, Nemer MM, Mao C, Young KA, Zhang J, Yu J, Freud AG, Oakes CC, Caligiuri MA. Epigenetic and Posttranscriptional Regulation of CD16 Expression during Human NK Cell Development. J Immunol. 2017 Dec 11. PMID: 29229679
  • Wing MR, Reeser JW, Smith AM, Reeder M, Martin D, Jewell BM, Datta J, Miya J, Monk JP, Mortazavi Am, Otterson GA, Goldberg RM, Vandeusen JB, Cole S, Dittmar, K, Jaiswal S, Kinzie M, Waikhom S, Freud AG, Zhou XP, Chen W, Bhatt D, Roychowdhury S. Analytic validation and real-time clinical application of an amplicon-based targeted gene panel for advanced cancer. Oncotarget. 2017 Sep 1;8(44):75822-75833. PMID: 29100271
  • Andritsos LA, Grieselhuber NR, Anghelina M, Rogers KA, Roychowdhury S, Reeser JW, Timmers CD, Freud AG, Blachly JS, Lucas DM, Lozanski G, Jones JA, Williams K, Oakes C, Jones D, Grever MR. Trametinib for the treatment of IGHV4-34, MAP2K1-mutant variant hairy cell leukemia. Leuk Lymphoma. 2017 Sep 18:1-4. PMID: 28918710
  • Victor AR, Nalin AP, Dong W, McClory S, Wei M, Mao C, Kladney RD, Youssef Y, Chan WK, Briercheck EL, Hughes T, Scoville SD, Pitarresi JR, Chen C, Manz S, Wu LC, Zhang J, Ostrowski MC, Freud AG, Leone GW, Caligiuri MA, Yu J. IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-κB. J Immunol. 2017 Aug 25. PMID: 28842466
  • Reeser JW, Martin D, Miya J, Kautto EA, Lyon E, Zhu E, Wing MR, Smith A, Reeder M, Samorodnitsky E, Parks H, Naik KR, Gozgit J, Nowacki N, Davies KD, Varella-Garcia M, Yu L, Freud AG, Coleman J, Aisner DL, Roychowdhury S. Validation of a Targeted RNA Sequencing Assay for Kinase Fusion Detection in Solid Tumors. J Mol Diagn. 2017 Aug 8. pii: S1525-1578(17)30114-9. PMID: 28802831
  • Haverkos BM, Huang Y, Gru A, Pancholi P, Freud AG, Mishra A, Stark A, Baiocchi RA, Porcu P. Frequency and clinical correlates of elevated plasma Epstein-Barr virus DNA at diagnosis in peripheral T-cell lymphomas (PTCL). Int J Cancer. 2017 Apr 15;140(8):1899-1906. PMID: 27943278
  • Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, Maisuria S, Keller MD, Togi S, Watkin LB, LaRosa DF, Jhangiani SN, Muzny DM, Stray-Pedersen A, Coban Akdemir Z, Smith JB, Hernández-Sanabria M, Le DT, Hogg GD, Cao TN, Freud AG, Szymanski EP, Savic S, Collin M, Cant AJ, Gibbs RA, Holland SM, Caligiuri MA, Ozato K, Paust S, Doody GM, Lupski JR, Orange JS. Biallelic mutations in IRF8 impair human NK cell maturation and function. J Clin Invest. 2017 Jan 3;127(1):306-320. PMID: 27893462
  • Mundy-Bosse BL, Scoville SD, Chen L, McConnell K, Mao HC, Ahmed EH, Zorko N, Harvey S, Cole J, Zhang X, Costinean S, Croce CM, Larkin K, Byrd JC, Vasu S, Blum W, Yu J, Freud AG, Caligiuri MA. MicroRNA-29b mediates altered innate immune development in acute leukemia. J Clin Invest. 2016 Dec 1;126(12):4404-4416. PMID: 27775550
  • Haverkos BM, Gru AA, Geyer SM, Bingman AK, Hemminger JA, Mishra A, Wong HK, Pancholi P, Freud AG, Caligiuri MA, Baiocchi RA, Porcu P. Increased Levels of Plasma Epstein Barr Virus DNA Identify a Poor-Risk Subset of Patients With Advanced Stage Cutaneous T-Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2016 Aug;16 Suppl:S181-S190.e4. PMID: 27521316
  • Freud AG, Keller KA, Scoville SD, Mundy-Bosse BL, Cheng S, Youssef Y, Hughes T, Zhang X, Mo X, Porcu P, Baiocchi RA, Yu J, Carson WE 3rd, Caligiuri MA. NKp80 defines a critical step during human natural killer cell development. Cell Rep. 2016 Jun 29.[Epub ahead of print]
  • Scoville SD, Mundy-Bosse BL, Zhang MH, Chen L, Zhang X, Keller KA, Hughes T, Chen L, Cheng S, Bergin SM, Mao HC, McClory S, Yu J, Carson WE 3rd, Caligiuri MA, Freud AG. Immunity. 2016 May 17;44(5):1140-50.
  • Scoville SD, Keller KA, Cheng S, Zhang M, Zhang X, Caligiuri MA, Freud AG. Rapid Column-Free Enrichment of Mononuclear Cells from Solid Tissues. Sci Rep. 2015 Jul 30;5:12490.
  • Deng Y, Kerdiles Y, Chu J, Yuan S, Wang Y, Chen X, Mao H, Zhang L, Zhang J, Hughes T, Deng Y, Zhang Q, Wang F, Zou X, Liu CG, Freud AG, Li X, Caligiuri MA, Vivier E, Yu J. Transcription factor foxo1 is a negative regulator of natural killer cell maturation and function. Immunity. 2015 Mar 17;42(3):457-70.
  • Hughes T, Briercheck EL, Freud AG, Trotta R, McClory S, Scoville SD, Keller K, Deng Y, Cole J, Harrison N, Mao C, Zhang J, Benson DM, Yu J, Caligiuri MA. The Transcription Factor AHR Prevents the Differentiation of a Stage 3 Innate Lymphoid Cell Subset to Natural Killer Cells. Cell Rep. 2014 Jul 10;8(1):150-62.
  • Metcalf RA, Monabati A, Vyas M, Roncador G, Gualco G, Bacchi CE, Younes SF, Natkunam Y, Freud AG. Myeloid cell nuclear differentiation antigen is expressed in a subset of marginal zone lymphomas and is useful in the differential diagnosis with follicular lymphoma. Hum Pathol. 2014 Aug;45(8):1730-6.
  • Freud AG, Wei S, Gitana GM, Natkunam Y, Atwater SK. Expression of the activating receptor, NKp46 (CD335), in human natural killer and T-cell neoplasia. Am J Clin Pathol. 2013 Dec;140(6):853-66.
  • Hughes T, Becknell B, Freud AG, McClory S, Briercheck E, Yu J, Mao C, Giovenzana C, Nuovo G, Wei L, Zhang X, Gavrilin MA, Wewers MD, Caligiuri MA. Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue. Immunity. 2010 Jun 25;32(6):803-14.