Jieli (Shirley) Li, MD, PhD
Assistant Professor-Clinical
Phone:
E-mail:
Mailing Address:
E314 Doan Hall
410 W 10th Ave.
Columbus, OH 43210
Biosketch
Jieli Shirley Li, MD, PhD, is an Assistant Professor-Clinical at the Department of Pathology, and Co-Director at the Clinical Chemistry&Toxicology Laboratory. Dr. Li earned her MD and PhD from Shanghai Jiao-Tong University School of Medicine. Dr. Li completed her fellowship training in clinical chemistry at MD Anderson Cancer Center. Her clinical service and academic interests focus on implementing innovate laboratory tests for in vitro diagnosis, prognosis and treatment planning of cancer and endocrine diseases. Dr. Li has published more than 40 scientific articles and served as Ad Hoc reviewer for 10 journals. She also serves as board of director in national societies.
Grants
Title: Comparison of human chorionic gonadotrophinβconcentrations in trophoblastic or non-trophoblastic tumors determined by different immunoassays and LC-MS/MS
Role: PI
Sponsor: North American Chinese Clinical Chemists Association (NACCCA)
Dates: 09/01/2019-08/31/2020
Academic and Medical Appointments
2019-Present Assistant Professor-Clinical, Department of Pathology, The Ohio State University Wexner Medical Center
2019-Present Co-Director, Clinical Chemistry&Toxicology Laboratory, The Ohio State University Wexner Medical Center
2014-2016 Research Assistant Professor, Department of Physiology and Biophysics, University of Illinois at Chicago
2002-2004 Resident Physician, Department of Internal Medicine, Shanghai the 8th People's Hospital, China
Education and Training
2017-2019 Clinical Chemistry Fellow, Department of Pathology, University of Texas MD Anderson Cancer Center
2011-2014 Post-Doctoral Fellow, Department of Physiology and Biophysics, University of Illinois at Chicago
2009-2011 Post-Doctoral Fellow, Department of Medical Physiology, Texas A&M University Health Science Center
2004-2009 Ph.D. in Endocrinology, Shanghai Jiao-Tong University School of Medicine, China
1997-2002 M.D. in Clinical Medicine, Shanghai Jiao-Tong University School of Medicine, China
Selected Publications
- Garnett E, Li J, Rajapakshe D, Tam E, Meng QH, Devaraj S. Efficacy of two vitamin D immunoassays to detect 25-OH vitamin D2 and D3. Pract Lab Med. 2019 Jul 29;17:e00130. [PMID: 31428669]
- Qdaisat A, Al Soud R, Wu CC, Rojas Hernandez CM, Li J, Meng QH, Abdel-Razeq H, Yeung SJ. Poor performance of D-Dimer in excluding venous thromboembolism among patients with lymphoma and leukemia. Haematologica. 2019 Jun;104(6):e265-e268. [PMID: 30630988]
- Li J and Meng QH. Factual or Factitious Hypocalcemia? J Appl Lab Med. 2018 518-520.
- Li J and Meng QH. A Patient with Severe Hyperkalemia. Clin Chem. 2018 Nov;64(11):1673. [PMID: 30377182]
- Li J, Ma J, Wagar EA, Liang D, Meng QH. A rapid ultra-performance LC-MS/MS assay for determination of serum unbound fraction of voriconazole in cancer patients. Clin Chim Acta. 2018 Nov;486:36-41. [PMID: 30016626]
- Li J, Wagar EA, Meng QH. Comprehensive Assessment of Biotin Interference in Immunoassays. Clin Chim Acta. 2018 Oct 5;487:293-298 [PMID: 30296442]
- Liu Y, Wang J, Li J, Wang R, Tharakan B, Zhang SL, Tong CW, Peng X. Deletion of Cdc42 in embryonic cardiomyocytes results in right ventricle hypoplasia. Clin Transl Med. 2017 Nov 3;6(1):40. [PMID: 29101495]
- Ryba DM, Li J, Cowan CL, Russell B, Wolska BM, Solaro RJ. Long-term biased β-arrestin signaling improves cardiac structure and function in dilated cardiomyopathy. Circulation. 2017 Mar 14;135(11):1056-1070. [PMID: 28104714]
- Li J, Liu Y, Jin Y, Wang R, Wang J, Lu S, VanBuren V, Dostal DE, Zhang SL, Peng X. Essential role of Cdc42 in cardiomyocyte proliferation and cell-cell adhesion during heart development. Dev Biol. 2017 Jan 15;421(2):271-283. [PMID: 27986432]
- Lin YH, Warren C, Li J, McKinsey TA, Russell B. Myofibril Growth During Cardiac Hypertrophy is Regulated Through Dual Phosphorylation and Acetylation of the Actin Capping Protein CapZ. Cell Signal. 2016 Aug;28(8):1015-24. [PMID: 27185186]
- Broughton KM*, Li J*, Sarmah E, Warren CM, Lin YH, Henze MP, Sanchez-Freire V, Solaro RJ, Russell B. A Myosin Activator improves Actin Assembly and Sarcomere Function of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes with a Troponin T Point Mutation. Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H107-17. [PMID: 27199119] [* co-first author]
- Li, J, Mkrtschjan, M, Lin, YH, Russell B. Variation in stiffness regulates cardiac myocyte hypertrophy via signaling pathways. Can J Physiol Pharmacol 2016 Jun 15:1-9. [PMID: 27486838]
- Lin YH, Swanson ER, Li J, Mkrtschjan MA, Russell B. Cyclic mechanical strain of myocytes modifies CapZβ1 post translationally via PKCε. J Muscle Res Cell Motil. 2015 Oct;36(4-5):329-37. [PMID: 26429793]
- Li J, Tanhehco EJ, Russell B. Actin dynamics is rapidly regulated by the PTEN and PIP2 signaling pathways leading to myocyte hypertrophy. Am J Physiol Heart Circ Physiol. 2014 Dec 1;307(11):H1618-25. [PMID: 25260617]
- Li J, Russell B. Phosphatidylinositol 4,5-bisphosphate regulates CapZβ1 and actin dynamics in response to mechanical strain. Am J Physiol Heart Circ Physiol. 2013 Dec 1;305(11):H1614-23. [PMID: 24043251]
- Liu Y, Jin Y, Li J, Seto E, Kuo E, Yu W, Schwartz RJ, Blazo M, Zhang SL, Peng X. Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects. Dev Biol. 2013 Nov 15; 383 (2):239-52. [PMID: 24056078]
- Jin Y, Liu Y, Lin Q, Li J, Druso JE, Antonyak MA, Meininger CJ, Zhang SL, Dostal DE, Guan JL, Cerione RA, Peng X. Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Mol Cell Biol. 2013 Nov;33(21):4181-97. [PMID: 23979594]
- Lin YH, Li J, Swanson ER, Russell B. CapZ and actin capping dynamics increase in myocytes after a bout of exercise and abates in hours after stimulation ends. J Appl Physiol. 2013 Jun;114(11):1603-9. [PMID: 23493359]
- Li JL, Zhao L, Cui B, Deng LF, Ning G, Liu JM. Osteoblast differentiation promoted by specific activation of N-methyl-D-aspartate (NMDA) receptors via multiple signaling pathways. Acta Pharmacol Sin 2011 Jul;32(7):895-903. [PMID: 21685927]
- Li JL, Cui B, Qi L, Li XY, Deng LF, Ning G, Liu JM. NMDA enhances stretching-induced differentiation of osteoblasts through the ERK1/2 signaling pathway. Bone. 2008 Sep;43(3):469-475. [PMID: 18573356]