Tatiana Oberyszyn, PhD
Professor and Vice Chair
Phone:
E-mail:
Mailing Address:
230 Meiling Hall
370 W. 9th Ave
Columbus, OH 43210
Biosketch
The research in my laboratory focuses on using the Skh-1 hairless murine preclinical model to understand the development of ultraviolet light induced squamous cell carcinoma of the skin. We design all of our studies taking into consideration the conditions in humans that contribute to the development of this most common cancer. Our murine model provides us with the opportunity to develop and test both preventive and treatment modalities that can then be applied to patients. We actively are testing a number of different topical and oral compounds as well as foods for potential use as chemopreventive and/or chemotherapeutic agents. We have used our mouse model to examine the effects of different therapeutically relevant immunosuppressive drugs, used by solid organ transplant patients, on UVB induced tumor development. Additionally we are examining differences in the skin and immune system of male and female mice in an attempt to understand why men develop three fold more ultraviolet light induced squamous cell carcinomas. We have shown that the increase in SCC development in male skin is not simply due to men spending more time outdoors, but rather that there are biological differences in the skin of males and females. I have 22 years of experience working with murine models studying the role of the inflammatory response in the development of keratinocyte cancers as well as in wound healing. I have been NIH funded continually for the last 18 years, have graduated 8 Ph.D. students and have mentored several postdoctoral fellows, undergraduate, high school and medical students.
Grants
Title: Post-transplant Cutaneous Squamous Cell Carcinoma and Macrophage Migration Inhibitory Factor.
Role: PI
Sponsor: NIH/NCI R21CA198024-01A1
Dates: 4/16/2016-3/31/2018
The major goals of this project are to test the efficacy of a novel topical inhibitor of MIF in preventing and/ or treating UV induced skin tumors in mice immunosuppressed with the therapeutically relevant immunosuppressive drugs Tacrolimus and MMF.
Academic and Medical Appointments
2015-present Professor, with tenure, Department of Pathology, The Ohio State University
2010-present Vice Chair for Academic Affairs, Department of Pathology, The Ohio State University
2009-present Jack C. Geer M.D., Endowed Professorship in Pathology, The Ohio State University
Education and Training
1994-2001 Research Scientist, Department of Molecular Virology, Immunology & Medical Genetics, The Ohio State University
1991-1994 Postdotoral Fellow, Departments of Surgery and Medical Microbiology and Immunology, The Ohio State University
1990-1991 Postdoctoral Fellow, General Surgery, University of Medicine and Dentistry of New Jersey
1986-1990 Ph.D., Rutgers University, New Brunswick, NJ
1980-1985 B.S., St. John's University, Jamaica, NY
Selected Publications
- Kopec RE, Schick J, Tober KL, Riedl KM, Francis DM, Young GS, Schwartz SJ, Oberyszyn TM. 2015. Sex differences in skin carotenoid deposition and acute UVB-induced skin damage in SKH-1 hairless mice after consumption of tangerine tomatoes. Mol Nutr Food Res. 2015. 59(12):2491-501. PMID: 26394800
- Gressel KL, Duncan FJ, Oberyszyn TM, La Perle KM and Everts HB. Endogenous Retinoic Acid Required to Maintain the Epidermis Following Ultraviolet Light Exposure in SKH-1 Hairless Mice. Photochem. Photobiology. 2015;91:901-908. PMID: 25715879
- Hill NT, Gracia-Maldonado GH, Leonard MK, Harper AR, Tober KL, Oberyszyn TM, Kadakia MP. "Role of Vitamin D₃ in modulation of ΔNp63α expression during UVB induced tumor formation in SKH-1 mice." PLOS One. 2014. 9(9):e107052. PMID: 25191969
- Nagarajan P, Tober KL, Riggenbach JA, Kusewitt DF, Lehman AM, Sielecki T, Pruitt J, Satoskar AR*, Oberyszyn TM*. Macrophage Migration Inhibitory Factor. Antagonist protects against Ultraviolet Light-induced Squamous Cell Carcinogenesis. *co-senior authors. Molecular Cancer Research. 2014. 12(9):1292-302. PMID: 24850900
- Perez CJ, Rundhaug JE, Johnson DG, Oberyszyn TM, Tober KL, Kusewitt DF. Slug expression in mouse skin and skin tumors is not regulated by p53. Journal of Investigative Dermatology. 2014; 134(2):566-568. PMID: 24008423
- Burns EM, Tober KL, Riggenbach JA, Kusewitt DF, Young GS, Oberyszyn TM. Differential effects of topical Vitamin E and C E Ferulic® treatments on ultraviolet light B-induced cutaneous tumor development in Skh-1 mice. PLoS One. 2013; 8(5):e63809. PMID: 23691100
- Burns EM, Tober KL, Riggenbach JA, Schick JS, Lamping KN, Kusewitt DR, Young GS, Oberyszyn TM. Preventative topical diclofenac treatment differentially decreases tumor burden in male and female Skh-1 mice in a model of UVB-induced cutaneous squamous cell carcinoma. Carcinogenesis. 2013; 34(2):370-377. PMID: 23125227
- Burns EM, Tober KL, Riggenbach JA, Kusewitt DF, Young GS, Oberyszyn TM. Extended UVB exposures alter tumorigenesis and treatment efficacy in a murine model of cutaneous squamous cell carcinoma. Journal of Skin Cancer. 2013; 2013:246848. PMID: 24286011
- Sullivan NJ, Tober KL, Burns EM, Schick JS, Riggenbach JA, Mace TA, Bill MA, Young GS, Oberyszyn TM, Lesinski GB. UV light B-mediated inhibition of skin catalase activity promotes Gr-1+ CD11b+ myeloid cell expansion. Journal of Investigative Dermatology. 2012; 132(3 Pt 1):695-702. PMID: 22030957
- Dhabhar FS, Saul AN, Holmes TH, Daugherty C, Neri E, Tillie JM, Kusewitt D, Oberyszyn TM. High-anxious individuals show increased chronic stress burden, decreased protective immunity, and increased cancer progression in a mouse model of squamous cell carcinoma. PLoS One. 2012: 7(4):e33069. PMID:22558071
- Wulff BC, Thomas-Ahner JM, Schick JS, Oberyszyn TM. Celecoxib reduces the effects of acute and chronic UVB exposure in mice treated with therapeutically relevant immunosuppressive drugs. International Journal of Cancer. 2010; 126(1):11-18. PMID:19609953
- Sullivan NJ, Sasser AK, Axel AE, Vesuna F, Raman V, Ramirez N, Oberyszyn TM*, Hall BM. Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene. 2009; 28(33):2940-2947. *Corresponding author PMID:19581928
- Wulff BC, Kusewitt DF, VanBuskirk AM, Thomas-Ahner JM, Duncan FJ, Oberyszyn TM. Sirolimus reduces the incidence and progression of UVB-induced skin cancer in SKH mice even with co-administration of cyclosporine A. Journal of Investigative Dermatology. 2008; 128(10):2467-2473. PMID:18463679
- Wulff BC, Schick JS, Thomas-Ahner JM, Kusewitt DF, Yarosh DB, Oberyszyn TM. Topical treatment with OGG1 enzyme affects UVB-induced skin carcinogenesis. Photochemistry and Photobiology. 2008; 84(2):317-321. PMID:18086242
- Tober KL, Thomas-Ahner JM, Maruyama T, Oberyszyn TM. Possible cross-regulation of the E prostanoid receptors. Molecular Carcinogenesis. 2007; 46(8):711-715. PMID:17538953
- Hatton JL, Parent A, Tober KL, Hoppes T, Wulff BC, Duncan FJ, Kusewitt DF, VanBuskirk AM, Oberyszyn TM. Depletion of CD4+ cells exacerbates the cutaneous response to acute and chronic UVB exposure. Journal of Investigative Dermatology. 2007; 127(6):1507-1515. PMID:17363918
- Thomas-Ahner JM, Wulff BC, Tober KL, Kusewitt DF, Riggenbach JA, Oberyszyn TM. Gender differences in UVB-induced skin carcinogenesis, inflammation, and DNA damage. Cancer Research. 2007; 67(7):3468-3474. PMID:17389759
- Tober KL, Wilgus TA, Kusewitt DF, Thomas-Ahner JM, Maruyama T, Oberyszyn TM. Importance of the EP(1) receptor in cutaneous UVB-induced inflammation and tumor development. Journal of Investigative Dermatology. 2006; 126(1):205-211. PMID:16417238
- Wilgus TA, Breza TS Jr, Tober KL, Oberyszyn TM. Treatment with 5-fluorouracil and celecoxib displays synergistic regression of ultraviolet light B-induced skin tumors. Journal of Investigative Dermatology. 2004; 122(6):1488-1494. PMID:15175041
- Wilgus TA, Koki AT, Zweifel BS, Kusewitt DF, Rubal PA, Oberyszyn TM. Inhibition of cutaneous ultraviolet light B-mediated inflammation and tumor formation with topical celecoxib treatment. Molecular Carcinogenesis. 2003; 38(2):49-58. PMID:14502644