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Steve Oghumu, PhD

Associate Professor

Steve Oghumu, PhD

Phone:

614-685-7556

E-mail:

Email Dr. Oghumu

Mailing Address:

248 Evans Hall
520 King Ave
Columbus, OH 43201

Biosketch

Dr. Oghumu’s research program is aimed at understanding the genetic and immunological factors underlying the etiology and pathogenesis of human disease. His research is focused on two primary disease areas: (i) oral carcinogenesis and (ii) substance use disorder. Using innovative mouse models, he is investigating the cellular, molecular and immunological mechanisms of oral carcinogenesis and advancing the development and application of compounds for oral cancer chemoprevention and treatment. He is also developing and applying uniquely novel mouse models to determine the contribution of X-chromosome inactivation to sex differences in susceptibility to neoplastic and neurologic disorders.

Grants

Title: X chromosome inactivation in sex disparities to substance use disorder

Role: PI

Sponsor: NIH/NIDA

Dates: 08/01/2021 - 05/30/2026


Title: Defining the role of the oral glucocorticoid system in oral carcinogenesis and its modulation for improved treatment outcomes

Role: PI

Sponsor: NIH/NIDCR

Dates: 08/01/2021 - 07/30/2022


Title: Mechanisms of MIF in Oral Cancer: Applications for Prevention and Treatment

Role: PI

Sponsor: American Cancer Society

Dates: 07/01/2019 - 06/30/2023


Title: Mechanisms of Oral Cancer Inhibition by Bioactive Phytochemicals in Black Raspberries

Role: PI

Sponsor: NIH/NCI

Dates: 09/01/2017 - 08/31/2022


Academic and Medical Appointments

2018-Present Assistant Professor, Department of Pathology, The Ohio State University, Columbus, OH

Education and Training

2015-2017 Research Scientist, College of Public Health, The Ohio State University, Columbus, OH

2011-2014 Postdoctoral Fellow, College of Dentistry, The Ohio State University, Columbus, OH

2007-2010 Ph.D. Microbiology, The Ohio State University, Columbus, OH

2004-2007 M.S. Microbiology, The Ohio State University, Columbus, OH

1998-2002 B.S. Microbiology, Ahmadu Bello University, NIGERIA

Selected Publications

Search in PubMed

  • Fatima N, Sheikh N, Satoskar AR, Akhtar T, Tayyeb A, Ashfaq I, Ryan N, Ambreen S, Jha BK, Oghumu S*. Effect of Short-Term Tacrolimus Exposure on Rat Liver: An Insight into Serum Antioxidant Status, Liver Lipid Peroxidation, and Inflammation. Mediators Inflamm. 2021; 2021:6613786. doi: 10.1155/2021/6613786. eCollection 2021. PubMed PMID: 33679236; PubMed Central PMCID: PMC7929660.
  • Anderson K, Ryan N, Alkhimovitch A, Siddiqui A, Oghumu S*. Inhibition of PI3K Isoform p110γ Increases Both Anti-Tumor and Immunosuppressive Responses to Aggressive Murine Head and Neck Squamous Cell Carcinoma with Low Immunogenicity. Cancers (Basel). 2021 Feb 25;13(5). doi: 10.3390/cancers13050953. PubMed PMID: 33668795; PubMed Central PMCID: PMC7956466.
  • Anderson K, Ryan N, Siddiqui A, Pero T, Volpedo G, Cooperstone JL, Oghumu S*. Black Raspberries and Protocatechuic Acid Mitigate DNFB-Induced Contact Hypersensitivity by Down-Regulating Dendritic Cell Activation and Inhibiting Mediators of Effector Responses. Nutrients. 2020 Jun 6;12(6). doi: 10.3390/nu12061701. PubMed PMID: 32517233; PubMed Central PMCID: PMC7352349.
  • Ryan N, Anderson K, Volpedo G, Varikuti S, Satoskar M, Satoskar S, Oghumu S*. The IL-33/ST2 Axis in Immune Responses Against Parasitic Disease: Potential Therapeutic Applications. Front Cell Infect Microbiol. 2020;10:153. doi: 10.3389/fcimb.2020.00153. eCollection 2020. Review. PubMed PMID: 32363166; PubMed Central PMCID: PMC7180392
  • Varikuti S, Singh B, Volpedo G, Ahirwar DK, Jha BK, Saljoughian N, Viana AG, Verma C, Hamza O, Halsey G, Holcomb EA, Maryala RJ, Oghumu S, Ganju RK, Satoskar AR. Ibrutinib treatment inhibits breast cancer progression and metastasis by inducing conversion of myeloid-derived suppressor cells to dendritic cells. Br J Cancer. 2020 Feb 6. doi: 10.1038/s41416-020-0743-8. [Epub ahead of print] PMID: 3202502
  • Anderson K, Ryan N, Volpedo G, Varikuti S, Satoskar AR, Oghumu S*. Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC. Front Immunol. 2020 Jan 15;10:3095. doi: 10.3389/fimmu.2019.03095. eCollection 2019. PMID: 32010142
  • Ryan N, Anderson K, Volpedo G, Hamza O, Varikuti S, Satoskar AR, Oghumu S*. STAT1 inhibits T cell exhaustion and myeloid derived suppressor cell accumulation to promote anti-tumor immune responses in head and neck squamous cell carcinoma. Int J Cancer. 2019 Nov 10. doi: 10.1002/ijc.32781. [Epub ahead of print] PMID:31709529
  • Knobloch TJ, Peng J, Hade EM, Cohn DE, Ruffin MT 4th, Schiano MA, Calhoun BC, McBee WC Jr, Lesnock JL, Gallion HH, Pollock J, Lu B, Oghumu S, Zhang Z, Sears MT, Ogbemudia BE, Perrault JT, Weghorst LC, Strawser E, DeGraffinreid CR, Paskett ED, Weghorst CM. Inherited alterations of TGF beta signaling components in Appalachian cervical cancers. Cancer Causes Control. 2019 Oct;30(10):1087-1100. doi: 10.1007/s10552-019-01221-y. Epub 2019 Aug 21. PMID: 31435875
  • Knobloch TJ, Ryan NM, Bruschweiler-Li L, Wang C, Bernier MC, Somogyi A, Yan PS, Cooperstone JL, Mo X, Brüschweiler RP, Weghorst CM, Oghumu S*. Metabolic Regulation of Glycolysis and AMP Activated Protein Kinase Pathways during Black Raspberry-Mediated Oral Cancer Chemoprevention. Metabolites. 2019 Jul 11;9(7). pii: E140. doi: 10.3390/metabo9070140. PMID: 31336728
  • Oghumu S*, Varikuti S, Stock JC, Volpedo G, Saljoughian N, Terrazas CA, Satoskar AR. Cutting Edge: CXCR3 Escapes X Chromosome Inactivation in T Cells during Infection: Potential Implications for Sex Differences in Immune Responses. J Immunol. 2019 Aug 15;203(4):789-794. doi: 10.4049/jimmunol.1800931. Epub 2019 Jun 28. PMID: 31253729
  • Balatti V, Oghumu S*, Bottoni A, Maharry K, Cascione L, Fadda P, Parwani A, Croce C, Iwenofu OH. MicroRNA profiling of salivary duct carcinoma versus Her2/Neu overexpressing breast carcinoma identify miR-10a as a putative breast related oncogene. Head Neck Pathol. 2018 Sept 26 [Epub ahead of print]
  • Oghumu S*, Casto BC, Ahn-Jarvis J, Weghorst LC, Maloney J, Geuy P, Horvath KZ, Bollinger CE, Warner BM, Summersgill KF, Weghorst CM, Knobloch TJ. Inhibition of pro-inflammatory and anti-apoptotic biomarkers during experimental oral cancer chemoprevention by dietary black raspberries. Front Immunol. 2017 Oct 23;8:1325. doi: 10.3389/fimmu.2017.01325
  • Varikuti S, Oghumu S*, Elbaz M, Volpedo G, Ahirwar DK, Alarcon PC, Sperling RH, Moretti E, Pioso MS, Kimble J, Nasser MW, Ganju RK, Terrazas C, Satoskar AR. STAT1 gene deficient mice develop accelerated breast cancer growth and metastasis which is reduced by IL-17 blockade. Oncoimmunology. 2017 Aug 14;6(11):e1361088. doi: 10.1080/2162402X.2017.1361088
  • Oghumu S*, Varikuti S, Saljoughian N, Terrazas C, Huntsman AC, Parinandi NL, Fuchs JR, Kinghorn AD, Satoskar AR. Pentalinonsterol, a constituent of Pentalinon andrieuxii, possesses potent immunomodulatory activity and primes T cell immune responses. J Nat Prod. 2017 Sep 22;80(9):2515-2523. doi: 10.1021/acs.jnatprod.7b00445. PMID: 28876059