Netty Santoso, PhD
Assistant Professor
Phone:
E-mail:
Mailing Address:
385A Wiseman Hall
400 W. 12th Ave
Columbus, OH 43210
Biosketch
Dr. Santoso's long-term research interest is to understand molecular mechanism underlying oncoviral pathogenicity. She uses functional genomics and systematic approaches to investigate the impact of oncoviruses infection on host genome and identify novel restriction factors involved in viral pathogenesis.
Academic and Medical Appointments
2021-presentTenure-track Assistant Professor - Department of Pathology, The Ohio State University College of Medicine
2018-2021Research Assistant Professor - Department of Pathology, The Ohio State University College of Medicine
Education and Training
Postdoctoral training, Harvard Medical School
PhD, Johns Hopkins School of Medicine
Bsc, Purdue University
Selected Publications
- Simpson S, Fiches G, Jean M, Dieringer M, McGuinness J, John S. Shamay, Desai P, Zhu J, Santoso N. Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi’s Sarcoma-associated HerpesVirus (KSHV) and Proliferation of KSHV-infected Tumor Cells (2018) Front Microbiol 9:788
- Jean MJ, Hayashi T, Huang H, Brennan J, Simpson S, Purmal A, Gurova K, Keefer MC, Kobie JJ, Santoso NG, Zhu J. Curaxin CBL0100 Blocks HIV-1 Replication and Reactivation through Inhibition of Viral Transcriptional Elongation (2017) Front Microbiol 8:2007
- Hayashi T, Jean M, Huang H, Simpson S, Santoso NG, Zhu J. Screening of an FDA-approved compound library indentifies Levisomendan as a novel anti-HIV-1 agent that inhibits viral transcription (2017) Antiviral Res 146:76-85
- Huang H, Liu S, Jean M, Simpson S, Huang H, Merkley M, Hayashi T, Kong W, Rodríguez-Sánchez I, Zhang X, Yosief HO, Miao H, Que J, Kobie JJ, Bradner J, Santoso NG, Zhang W, Zhu J. A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and PTEF-b Association. (2017) Front Microbiol 8:1035
- Jean MJ, Power D, Kong W, Huang H, Santoso N*, Zhu J*. Identification of HIV-1 Tat-associated proteins contributing to HIV-1 transcription and latency (2017) Viruses 9(4). pii: E67 (* indicates co-corresponding authors)
- Huang H, Santoso N, Power D, Simpson S, Dieringer M, Miao H, Gurova K, Giam CZ, Elledge S, Zhu J. FACT Proteins, SUPT16H and SSRP1, are Transcriptional Suppressors of HIV-1 and HTLV-1 that Facilitate Viral Latency (2015) J. Biol. Chem 290 (45): 27297-310
- The TCGA Consortium (including Santoso N) Genomic Classification of Cutaneous Melanoma (2015) Cell 161(7):1681-96
- Power D*, Santoso N*, Dieringer M, Yu J,Huang H, Simpson S, Seth I, Miao H, Zhu J. IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency (2015) Virology 481:142-150 (* indicates equal contribution by both authors)
- The TCGA Consortium (including Santoso N) Comprehensive genomic characterization of head and neck squamous cell carcinomas (2015) Nature 517(7536):576-82
- The TCGA Consortium (including Santoso N) Integrated genomic characterization of papillary thyroid carcinoma (2014) Cell 159(3):676-90
- Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis A, Ivanova E, Wilkerson MD, Protopopov A, Yang L, Seth S, Song X, Tang J, Ren X, Zhang J, Pantazi A, Santoso N, Xu AW, Mahadeshwar H, Wheeler DA, Haddad RI, Jung J, Ojesina AI, Isaeva N, Yarbrough WG, Hayes DN, Grandis JR, El-Naggar AK, Meyerson M, Park PJ, Chin L, Seidman JG, Hammerman PS, Kucherlapati R, TCGA Network. Characterization of HPV and host-genome interactions in primary head and neck cancers (2014) PNAS 111(43):15544-9
- Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, Hacker KE, Bhanot G, Gordenin DA, Chu A, Gunaratne PH, Biehl M, Seth S, Kaipparettu BA, Bristow CA, Donehower LA, Wallen EM, Smith AB, Tickoo SK, Tamboli P, Reuter V, Schmidt LS, Hsieh JJ, Choueiri TK, Hakimi AA, The TCGA Consortium (including Santoso N), Chin L, Meyerson M, Kucherlapati R, Park WY, Robertson AG, Laird PW, Henske EP, Kwiatkowski DJ, Park PJ, Morgan M, Shuch B, Muzny D, Wheeler DA, Linehan WM, Gibbs RA, Rathmell WK, Creighton CJ. The somatic genomic landscape of chromophobe renal cell carcinoma (2014) Cancer Cell 26(3):319-330
- The TCGA Consortium (including Santoso N*) Comprehensive molecular characterization of gastric adenocarcinoma (2014) Nature 513(7517):202-209
- The TCGA Consortium (including Santoso N) Comprehensive Molecular Profiling of Lung Adenocarcinoma (2014) Nature 511(7511):543-550
- The TCGA Consortium (including Santoso N*) Comprehensive molecular characterization of urothelial bladder carcinoma (2014) Nature 507(7492):315-322
- The TCGA Consortium (including Santoso N) The Cancer Genome Atlas Pan-Cancer analysis project (2013) Nat. Genet. 45(10):1113-1120
- Santoso NG, Cebotaru L, and Guggino WB. Polycystin-1,2, and STIM1 interact with IP3R to modulate ER Ca2+ release through the PI3K/Akt pathway (2011) Cell Physiol Biochem. 27(6):715-726
- Li Y*, Santoso NG*, Yu S, Woodward OM, Qian F, Guggino WB. Polycystin-1 interacts with IP3R to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease (2009) J. Biol. Chem. 284(52):36431-36441 (* indicates equal contribution by both authors)