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Konstantin Shilo, MD

Associate Professor-Clinical

Konstantin Shilo, MD

Phone:

614-366-3534

E-mail:

Email Dr. Shilo

Mailing Address:

E412 Doan Hall
410 West 10th Ave
Columbus, OH 43210

Biosketch

As a thoracic pathologist my interests in tumor biology are related to studies of protein expression. Tissue proteins represent a final functional element of gene expression, and as such are important targets for diagnosis, prognostication and treatment. In recent collaborative projects including interdisciplinary teams, we identified further evidence that gene methylation and tumor microenvironment play an important role in aggressiveness and metastasis. In a study of protein arginine methyltransferase-5 (PRMT5), a chromatin-modifying enzyme capable of methylating histone and non-histone proteins, we showed that PRMT5 plays an important role in lung tumorigenesis and its cellular localization correlates with tumor grade reflecting its functional dichotomy in cellular compartments. Targeted therapies have revolutionized lung cancer treatments in recent years; however, frequencies of targetable mutations in non-small cell lung carcinoma (NSCLC) vary among patient populations. Employing novel sequencing techniques we investigated molecular profile of a large cohort of patients of African American ancestry and showed that it may not be significantly different from European/white background for the presence of somatic driver mutations in NSCLC suggesting that a comprehensive genotyping approach could identify targetable alterations with potential impact on treatment in that population. My research interests in the field of interstitial lung diseases (ILD) are guided by the clinical needs of a large university center. Collaborative efforts include projects evaluating lung toxicity in the setting of solid organ transplantation as well as in evaluation of lung toxicity in genetically modified viral infection and mechanisms of acute lung injury.

Board Certifications

2003 Anatomic and Clinical Pathology, American Board of Pathology

Academic and Medical Appointments

2010-Present Director, Thoracic Pathology Division, Department of Pathology, The Ohio State University, Columbus, OH

2004-2009 Pathologist, Department of Pulmonary & Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC

Education and Training

2003-2004 Fellowship, Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC

1998-2003 Resident, Anatomical & Clinical Pathology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH

1982-1998 M.D., St. Petersburg Pediatric Medical Institute, Russia

Selected Publications

Search in PubMed

  • Shaker N, Shilo K, Esnakula AK, Shafi S, Challa B, Patel A, Kellough DA, Hammond S, Javaid S, Satturwar S, Yearsley MM, Li Z, Limbach AL, Lujan G, Parwani AV. Comparison of four different displays for identification of select pathologic features extracted from whole slide images of surgical pathology cases. Pathol Res Pract. 2023 Oct 2;251:154843. doi: 10.1016/j.prp.2023.154843. Epub ahead of print. PMID: 37826873.
  • Sebastian NT, Webb A, Shilo K, Robb R, Xu-Welliver M, Haglund K, Brownstein J, DeNicola GM, Shen C, Williams TM. A PI3K gene expression signature predicts for recurrence in early-stage non-small cell lung cancer treated with stereotactic body radiation therapy (SBRT). Cancer. 2023 Aug 10. doi: 10.1002/cncr.34983. Epub ahead of print. PMID: 37560930.
  • Shaker N, Amadi CC, Ganapathi AM, Satturwar S, Shilo K. Pulmonary Histoplasmosis Complicated by Nonvalvular Right Ventricular Wall Histoplasma capsulatum Endocarditis. Int J Surg Pathol. 2023 Jul 10:10668969231185079. doi: 10.1177/10668969231185079. Epub ahead of print. PMID: 37424325.
  • Shaker N, Amadi CC, Welliver M, Otterson GA, Liebner DA, Shilo K. A case of mediastinal carcinosarcoma with beta-HCG production and KRAS mutation. Int J Surg Pathol. 2023 Apr 3:10668969231166297. doi: 10.1177/10668969231166297. Epub ahead of print. PMID: 37013353.
  • Shilo K, Kneuertz PJ, Liebner DA, Chen W. Pulmonary synovial sarcoma in a long-term survivor of childhood Hodgkin lymphoma. Front Oncol. 2023 Feb 24;13:1096160. doi: 10.3389/fonc.2023.1096160. eCollection 2023. PMID: 36910640
  • Daniel VC, Shilo K. Two Thymomas of Different Histological Subtypes Arising in a Giant Thymolipoma: Case Report and Review of the Literature. Int J Surg Pathol. 2022 Nov 27:10668969221137523. doi: 10.1177/10668969221137523. Epub ahead of print. PMID: 36437637.
  • Ahirwar DK, Charan M, Mishra S, Verma AK, Shilo K, Ramaswamy B, Ganju RK. Slit2 inhibits breast cancer metastasis by activating M1-like phagocytic and anti-fibrotic macrophages. Cancer Res. 2021 Aug 16:canres.3909.2020. doi: 10.1158/0008-5472.CAN-20-3909. Epub ahead of print. PMID: 34400395.
  • Wang WZ, Shilo K, Amann JM, Shulman A, Hojjat-Farsangi M, Mellstedt H, Schultz J, Croce CM, Carbone DP. Predicting ROR1/BCL2 combination targeted therapy of small cell carcinoma of the lung. Cell Death Dis. 2021 Jun 4;12(6):577. doi: 10.1038/s41419-021-03855-w. PMID: 34088900.
  • Sloan SL, Renaldo KA, Long M, Chung JH, Courtney LE, Shilo K, Youssef Y, Schlotter S, Brown F, Klamer BG, Zhang X, Yilmaz AS, Ozer HG, Valli VE, Vaddi K, Scherle P, Alinari L, Kisseberth WC, Baiocchi RA. Validation of protein arginine methyltransferase 5 (PRMT5) as a candidate therapeutic target in the spontaneous canine model of non-Hodgkin lymphoma. PLoS One. 2021 May 14;16(5):e0250839. doi: 10.1371/journal.pone.0250839. PMID: 33989303; PMCID: PMC8121334.
  • Shields PG, Song MA, Freudenheim JL, Brasky TM, McElroy JP, Reisinger SA, Weng DY, Ren R, Eissenberg T, Wewers MD, Shilo K. Lipid laden macrophages and electronic cigarettes in healthy adults. EBioMedicine. 2020 Oct;60:102982. doi: 10.1016/j.ebiom.2020.102982. Epub 2020 Sep 10. PMID: 32919101; PMCID: PMC7494450.
  • Ballash GA, Schober KE, Haw SR, Shilo K, Jennings RN. Idiopathic pulmonary arterial hypertension in a pot-bellied pig (Sus scrofa domesticus) with right-sided congestive heart failure. J Vet Cardiol. 2020 Oct;31:1-7. doi: 10.1016/j.jvc.2020.07.001. Epub 2020 Jul 31. PMID: 32836069.
  • Shukuya T, Ghai V, Amann JM, Okimoto T, Shilo K, Kim TK, Wang K, Carbone DP. Circulating miRNAs and extracellular vesicle containing miRNAs as response biomarkers of anti PD-1/PD-L1 therapy in non-small-cell lung cancer. J Thorac Oncol. 2020 Jun 18:S1556-0864(20)30467-6. doi: 10.1016/j.jtho.2020.05.022. Epub ahead of print. PMID: 32565389.
  • Kneuertz PJ, Carbone DP, D'Souza DM, Shilo K, Abdel-Rasoul M, Zhao W, Williams TM, Jones D, Merritt RE. Prognostic value and therapeutic implications of expanded molecular testing for resected early stage lung adenocarcinoma. Lung Cancer. 2020 Mar 18;143:60-66. doi: 10.1016/j.lungcan.2020.03.012. [Epub ahead of print] PubMed PMID: 32208298.
  • Mei P, Shilo K, Wei L, Shen R, Tonkovich D, Li Z. Programmed cell death ligand 1 expression in cytologic and surgical non-small cell lung carcinoma specimens from a single institution: Association with clinicopathologic features and molecular alterations. Cancer Cytopathol. 2019 Apr 26. doi: 10.1002/cncy.22140. [Epub ahead of print] PubMed PMID: 31025831.
  • Duan W, Gao L, Kalvala A, Aguila B, Brooks C, Mo X, Ding H, Shilo K, Otterson GA, Villalona-Calero MA. Type of TP53 mutation influences oncogenic potential and spectrum of associated K-ras mutations in lung-specific transgenic mice. Int J Cancer. 2019 Mar 15. doi: 10.1002/ijc.32279. [Epub ahead of print] PubMed PMID: 30873587.
  • Arasada RR, Shilo K, Yamada T, Zhang J, Yano S, Ghanem R, Wang W, Takeuchi S, Fukuda K, Katakami N, Tomii K, Ogushi F, Nishioka Y, Talabere T, Misra S, Duan W, Fadda P, Rahman MA, Nana-Sinkam P, Evans J, Amann J, Tchekneva EE, Dikov MM, Carbone DP. Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC. Nat Commun. 2018 Aug 10;9(1):3198. doi: 10.1038/s41467-018-05626-2. PubMed PMID: 30097569
  • Lee LJ, Yang Z, Rahman M, Ma J, Kwak KJ, McElroy J, Shilo K, Goparaju C, Yu L, Rom W, Kim TK, Wu X, He Y, Wang K, Pass HI, Nana-Sinkam SP. Extracellular mRNA Detected by Tethered Lipoplex Nanoparticle Biochip for Lung Adenocarcinoma Detection. Am J Respir Crit Care Med. 2016 Jun 15;193(12):1431-3.
  • Elbaz M, Ahirwar D, Xiaoli Z, Zhou X, Lustberg M, Nasser MW, Shilo K, Ganju RK. TRPV2 is a novel biomarker and therapeutic target in triple negative breast cancer. Oncotarget. 2016 May 27.
  • Siegele BJ, Shilo K, Chao BH, Carbone DP, Zhao W, Ioffe O, Franklin WA, Edelman MJ, Aisner DL. Epidermal growth factor receptor (EGFR) mutations in small cell lung cancers: Two cases and a review of the literature. Lung Cancer. 2016 May;95:65-72.