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Shaoli Sun, MD

Professor-Clinical

Shaoli Sun, MD

Phone:

614-366-1831

E-mail:

Email Dr. Sun

Mailing Address:

S305E Rhodes Hall
410 W. 10th Ave.
Columbus, OH 43210

Biosketch

I received my MD from Zhengzhou University School of Medicine in China, did my AP/CP residency in Icahn School of Medicine at Mount Sinai in New York City and became a gastrointestinal (GI) pathologist after learning GI pathology from the most knowledgeable and inspiriting mentor Dr. Rodger Haggitt. As a practicing GI pathologist for more than 20 years, I approach the daily work as a process of solving medical puzzles. With clinical team and colleague’s support, it is a rewarding and exciting career with tremendous responsibility. However, very often I encounter questions with no answers and disease with no treatment. There are so many unknowns in biology and medicine waiting there for us to decipher. Working in an academic medical environment allows me to be a part of making discoveries. I also enjoy engaging students, residents, fellows, junior faculty and other trainees to join this journey. It is my belief and goal that by working together we can advance the field of medicine at a much faster pace to deliver better care to patients. I am also increasingly interested in machine/deep learning in digital pathology. I strive to make impact in both clinical medicine and research discovery.

Board Certifications

American Board of Pathology, Anatomic and Clinical Pathology

Academic and Medical Appointments

2020-Present Professor, Department of Pathology, The Ohio State University, Columbus, OH

2015-2020 Professor, Medical University of South Carolina, Pathology and Laboratory Medicine, Charleston SC

Education and Training

1998-1999 Fellow, Fred Hutchinson Cancer Research Center, Seattle, WA

1997-1999 Visiting GI Pathologist-in-Training with Drs. Rodger Haggitt,and Mary Bronner, Surgical Pathology, University of Washington, Seattle, WA

1993-1997 Internship and residency, AP/CP, Mount Sinai School of Medicine, New York, NY

1979-1984 MD, Henan Medical University, China

Selected Publications

Search in PubMed

  • Salem M, Wallace C, Li A, Ansa-Addo E, Metelli A, Kwon H, Velegraki A, Riesenberg B, Bill Wu1, Zhang Y, Guglietta S, Sun S, Liu B and Li Z (2019) GARP dampens cancer immunity by sustaining Treg cell function and homing to site of inflammation via CD103. Cancer Res (in press)
  • Emanuel AJ, Holman N, Presnell SE, Welsh CT, Pai S, Sun S. Small Bowel Mucosal Involvement and Mesenteric Mass Formation in a Young Female with Type 3 Gaucher Disease. A Case Report. J Gastrointestin Liver Dis. 2018 Dec;27(4):459-463.
  • Wallace K, Lewin DN, Sun S, Spiceland CM, Rockey DC, Alekseyenko AV, Wu JD, Baron JA, Alberg AJ, Hill EG. Tumor-Infiltrating Lymphocytes and Colorectal Cancer Survival in African American and Caucasian Patients. Cancer Epidemiol Biomarkers Prev. 2018 Jul;27(7):755-761.
  • Wallace CH, Wu BX, Salem M, Ansa-Addo EA, Metelli A, Sun S, Gilkeson G, Liu B and Li Z. B lymphocytes confer immune tolerance via cell surface GARP-TGF􀀀 complex. JCI Insight 2018 3(7). pii: 99863. doi: 10.1172/jci.insight.99863.
  • Hong F, Liu B, Wu BX, Morrell J, Roth B, Davies C, Sun S, Diehl JA and Li Z. CNPY2 is a Key Initiator of PERK-CHOP Pathway of the Unfolded Protein Response. Nat Struct Mol Biol 2017, 24(10):834-839. Highlighted by Nat Struct Mol Biol: Hery Urra & Claudio Hetz: Fine-tuning PERK signaling to control cell fate under stress - pp789 - 790 doi:10.1038/nsmb.3478
  • Hua Y, Yang Y, Sun S, Westwater C, Reizis B, Li Z and Liu B. Gut homeostasis and regulatory T cell induction depend on molecular chaperone gp96 in CD11c+ cells. Sci Rep 2017, 7(1):2171. doi: 10.1038/s41598-017-02415-7
  • Ansa-Addo EA, Zhang Y, Yang Y, Hussey GS, Howley BV, Sun S, Rockey DC, Karvar S, Howe PH, Liu B and Li Z. Membrane-organizing protein moesin controls Treg differentiation and anti-tumor immunity via TGF-β signaling. J Clin Invest 2017 Mar 13. pii: 89281. doi: 10.1172/JCI89281.
  • Lewis K, Butts R, Antonio Quiros J, Hudspeth M, Twombley K, Savage A, Self S, Burnette A, Sun S. Autoimmune enteropathy and hepatitis in pediatric heart transplant recipient. Pediatr Transplant 2017 Jan 17. doi: 10.1111/petr.12877. PMID: 28097735
  • Metelli A, Wu BX, Fugle CW, Rachidi S, Sun S, Zhang Y, Wu J, Tomlinson S, Howe PH, Yang Y, Garrett-Mayer E, Liu B, Li Z. Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer. Cancer Res 2016 Dec 15;76(24):7106-7117. PMID: 27913437
  • Wallace K, DeToma A, Lewin DN, Sun S, Rockey D, Britten CD, Wu JD, Ba A, Alberg AJ, Hill EG. Racial Differences in Stage IV Colorectal Cancer Survival in Younger and Older Patients. Clin Colorectal Cancer 2017; 16(3):178-186. PMID: 28065664
  • Fugle CW, Zhang Y, Hong F, Sun S, Westwater C, Rachidi S, Yu H, Garret-Mayer E, Kirkwood K, Liu B, Li Z. CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells. Oncoimmunology 2016 Sep 26;5(10):e1226719. PMID: 27853649
  • Rachidi S, Sun S, Wu BX, Jones E, Drake RR, Ogretmen B, Cowart LA, Clarke CJ, Hannun YA, Chiosis G, Liu B, Li Z. Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. J Hepatol 2015; 62(4):879-88. PMCID: PMC4369194.
  • Rachidi S, Sun S, Li Z. Endoplasmic reticulum heat shock protein gp96/grp94 is a prooncogenic chaperone, not a tumor suppressor. Hepatology 2015 May;61(5):1766-7. doi: 10.1002/hep.27400. Epub 2015 Mar 23. PubMed PMID: 25163410.
  • Zhang Y, Wu BX, Metelli A, Thaxton JE, Hong F, Rachidi S, Ansa-Addo E, Sun S, Vasu C, Yang Y, Liu B, Li Z. GP96 is a GARP chaperone and controls regulatory T cell functions. J Clin Invest 2015 Feb;125(2):859-69. doi: 10.1172/JCI79014. Epub 2015 Jan 20. PubMed PMID: 25607841; PubMed Central PMCID: PMC4319419.
  • J Zhang, S Fu, Sun S, Z Li, B Guo. Inflammasome activation has an important role in the development of spontaneous colitis Journal name. Mucosal Immunol 2014 Jan 29. doi: 10.1038/mi.2014.1. [Epub ahead of print]
  • Knackstedt R, Sun S, Moseley V, Wargovich M. The importance of the retinoid X receptor alpha in modulating inflammatory signaling in acute murine colitis. Dig Dis Sci 2014 Apr;59(4):753-9. doi: 10.1007/s10620-013-2902-8. Epub 2013 Oct 22.
  • Zhang Y, Helke KL, Coelho SG, Valencia JC, Hearing VJ, Sun S, Liu B, Li Z. Essential role of the molecular chaperone gp96 in regulating melanogenesis. Pigment Cell Melanoma Res 2014 Jan;27(1):82-9. doi: 10.1111/pcmr.12165. Epub 2013 Oct 9
  • Morales C, Rachidi S, Hong F, Sun S, Ouyang X, Wallace C, Zhang Y, Garret-Mayer E, Wu J, Liu B, Li Z. Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis. Cancer Res 2014; 74(2):446-59. PMCID: PMC4002507.