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Hiroki Taniguchi, PhD

Associate Professor

Hiroki Taniguchi, PhD

Phone:

614-366-1191

E-mail:

Email Dr. Taniguchi

Office Location:

4184 Graves Hall
333 W. 10th Avenue
Columbus, OH 43210

Biosketch

Dr. Taniguchi has pursued molecular/cellular neurobiology as a research group leader at Max Planck Florida Institute for 9 years before joining the OSU. His research interests are focused on the molecular/cellular mechanisms underlying development and remodeling of cortical inhibitory circuits that play a critical role in brain computations and plasticity. His research programs should provide basic insight into functional recovery of the damaged or diseased brain. He would like to contribute to developing therapeutic strategies for brain damages/diseases from the point of view of basic neurobiology

Cortical inhibitory interneurons play a pivotal role in balancing/shaping brain activity as well as inducing neuronal plasticity. In addition, it has been shown that interneurons exhibit structural remodeling in the earliest phase of plastic changes in cortical circuits in response to sensory deprivation. Despite their implications in cortical functions and plasticity, molecular/cellular mechanisms underlying development and plasticity of interneuronal circuits remain largely unknown. Furthermore, little is known about the functional significance of interneuronal structural remodeling in cortical circuit plasticity. Cortical interneurons comprise diverse neuronal subtypes, each of which establishes specific local circuits and mediates a unique inhibitory function, and thus need to be dissected in a cell-type specific manner. Taking advantage of genetic approaches that enable a cell-type specific dissection, Dr. Taniguchi's team will tackle the above questions. He hopes the outcome from his research will provide the basis for reconstructing functional neuronal circuits in the damaged/diseased brain.

Research Interests:

  • Chronic pain
  • Experience-dependent cortical development
  • Cancer-brain interaction
  • Cortical interneurons
  • Neuronal diversity
  • Cortical plasticity

Academic and Medical Appointments

2021-Present Associate Professor, Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH

2012-2021 Research Group Leader, Max Planck Florida Institute

Education and Training

2011-2012 Research Investigator, Cold Spring Harbor Laboratory

2005-2011 Postdoctoral Fellow, Cold Spring Harbor Laboratory

2002-2005 Postdoctoral Fellow, Columbia University

2000 Ph.D. The Graduate University for Advanced Studies at National Institute for Basic Biology, Japan

1998-2002 Postdoctoral Fellow, National Institute for Basic Biology, Japan

1995-1998 Ph.D. student, The Graduate University for Advanced Studies at National Institute for Basic Biology, Japan

Selected Publications

Search in PubMed

  • Steinecke, A., Bolton, M.M., and H. Taniguchi. Neuromodulatory control of inhibitory network arborization in the developing postnatal neocortex. Sci Adv. 2022 Mar 11;8(10):eabe7192. doi: 10.1126/sciadv.abe7192.
  • Hayano, Y., Ishino, Y., Hyun, J.H., Orozco, C., Steinecke, A., Potts, E., Oisi, Y., Thomas, C., Guerrero-Given, D., Kim, E., Kwon, H-B., Kamasawa, N., and H. Taniguchi. IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype. Sci Adv. 2021 Jul 14;7(29):eabf1600. doi: 10.1126/sciadv.abf1600.
  • Steinecke, A., Kurabayashi, N., Hayano, Y., Ishino, Y., and H. Taniguchi. (2019). In vivo single cell genotyping of mouse cortical neurons transfected with CRISPR/ Cas9. Cell Reports, Volume 28, Issue 2, P325-331.E4, July 09.
  • Yetman, M.J., Washburn,E., Hyun, J.H., Osakada, F., Hayano, Y., Zeng, H., Callaway, E.M., Kwon, H., and H. Taniguchi. (2019). Intersectional Monosynaptic Tracing for Dissecting Subtype-Specific Organization of GABAergic Interneuron Inputs. Nature Neurscience, Mar;22(3):492-502. doi: 10.1038/s41593-018-0322-y. Epub 2019 Jan 28.
  • Rowan, M.J.M., Bonnan, A., Zhang, K., Amat, S.B., Patino,E., Kikuchi, C., Augustin, G.J., Taniguchi, H., and J.M. Christie. (2018). Graded Control of Climing Fiber- mediated Plasticity and Learning by Inhibition in the Cerebellum. Neuron Sep 5;99(5):999-1015.
  • Ishino, Y., Yetman, M.J., Sossi, S.M., Steinecke, A., Hayano, Y., and H. Taniguchi. (2017). Regional Cellular Environment Shapes Phenotypic Variations of Hippocampal and Neocortical Chandelier Cells. J Neurosci 37, 9901-9916.
  • Steinecke, A., Hozhabri, E., Tapanes, S., Ishino, Y., Zeng, H., Kamasawa, N., and H. Taniguchi. (2017). Neocortical Chandelier Cells Developmentally Shape Axonal Arbors through Reorganization but Establish Subcellular Synapse Specificity without Refinement. eNeuro 4.
  • Amat, S.B., Rowan, M.J.M., Gaffield, M.A., Bonnan, A., Kikuchi, C., Taniguchi, H., and J.M. Christie. (2017). Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice. PLoS One 12, e0179347.
  • Wall, N.R., De La Parra, M., Sorokin, J.M., Taniguchi, H., Huang, Z.J., and E.M. Callaway. (2016). Brain-Wide Maps of Synaptic Input to Cortical Interneurons. J Neurosci 36, 4000-4009.
  • Miyoshi, G., Young, A., Petros, T., Karayannis, T., McKenzie Chang, M., Lavado, A., Iwano, T., Nakajima, M., Taniguchi, H., Huang, Z.J., et al. (2015). Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons. J Neurosci 35, 12869-12889.
  • Basu, J., Srinivas, K.V., Cheung, S.K., Taniguchi, H., Huang, Z.J., and S.A. Siegelbaum. (2013). A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow. Neuron 79, 1208-1221.
  • Li, H., Penzo, M.A., Taniguchi, H., Kopec, C.D., Huang, Z.J., and B. Li. (2013). Experience-dependent modification of a central amygdala fear circuit. Nat Neurosci 16, 332-339.
  • Kvitsiani, D., Ranade, S., Hangya, B., Taniguchi, H., Huang, J.Z., and A. Kepecs. (2013). Distinct behavioural and network correlates of two interneuron types in prefrontal cortex. Nature 498, 363-366.
  • Nienborg, H., Hasenstaub, A., Nauhaus, I., Taniguchi, H., Huang, Z.J., and E.M. Callaway. (2013). Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing neurons to spatial integration in mouse V1. J Neurosci 33, 11145-11154.
  • Taniguchi, H., Lu, J., and Z.J. Huang. (2013). The spatial and temporal origin of chandelier cells in mouse neocortex. Science 339, 70-74.
  • Adesnik, H., Bruns, W., Taniguchi, H., Huang, ZJ., and M. Scanziani. (2012). A neural circuit for spatial summation in visual cortex. Nature 490(7419):226-31. doi: 10.1038/nature11526.
  • Gentet, L.J., Kremer, Y., Taniguchi, H., Huang, Z.J., Staiger, J.F., and C.C. Petersen. (2012). Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex. Nat Neurosci 15, 607-612.
  • Lee, S.H., Kwan, A.C., Zhang, S., Phoumthipphavong, V., Flannery, J.G., Masmanidis, S.C., Taniguchi, H., Huang, Z.J., Zhang, F., Boyden, E.S., et al. (2012). Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature 488, 379-383.
  • Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsiani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011). A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron 71, 995-1013.
  • Miyamichi, K., Amat, F., Moussavi, F., Wang, C., Wickersham, I., Wall, N.R., Taniguchi, H., Tasic, B., Huang, Z.J., He, Z., et al. (2011). Cortical representations of olfactory input by trans-synaptic tracing. Nature 472, 191-196.
  • Taniguchi, H., Gollan, L., Scholl, F.G., Mahadomrongkul, V., Dobler, E., Limthong, N., Peck, M., Aoki, C., and P. Scheiffele. (2007). Silencing of neuroligin function by postsynaptic neurexins. J Neurosci 27, 2815-2824.