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Gary Tozbikian, MD

Associate Professor-Clinical

Gary Tozbikian, MD

Phone:

614-366-8467

E-mail:

Email Dr. Tozbikian

Mailing Address:

E414 Doan Hall
410 W. 10th Ave
Columbus, OH 43210

Biosketch

Dr. Tozbikian is an Anatomic and Clinical Pathology board-certified Surgical Pathologist with a specialization in Breast Pathology. His research is focused on diagnostic, predictive, and therapeutic biomarkers for use in breast cancer, as well as the practical application of advanced digital imaging technology in breast pathology. After earning his MD degree from The Ohio State University, he completed his Pathology Residency and General Surgical Pathology Fellowship at the Hospital of the University of Pennsylvania, and Breast Pathology Fellowship at Memorial Sloan Kettering Cancer Center. Dr. Tozbikian joined the Department of Pathology at The Ohio State University Wexner Medical Center in 2013. He is an Associate Professor and Breast Pathology Division Director, and serves as a subspecialty pathologist on the breast and genitourinary pathology services.

Board Certifications

2011 Anatomic and Clinical Pathology, American Board of Pathology

Academic and Medical Appointments

2020-Present Associate Professor, Breast and Genitourinary Divisions, Department of Pathology, The Ohio State University, Columbus Ohio.

2013-2020 Assistant Professor, Breast and Genitourinary Divisions, Department of Pathology, The Ohio State University, Columbus Ohio.

2015-Present Director, Breast Pathology Division, Department of Pathology, The Ohio State University, Columbus Ohio.

Education and Training

2012-2013 Fellow, Breast Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY

2011-2012 Fellow, General Surgical Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA

2007-2011 Resident, Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA

2002-2007 M.D., The Ohio State University College of Medicine, Columbus, OH

Selected Publications

Search in PubMed

  • Gordian-Arroyo, A, Zynger D, Tozbikian G. Impact of the 2018 ASCO/CAP HER2 Guideline Focused Update. Accepted for publication in the Am J Clin Pathol (1/15/2019)
  • Gibbons-Fideler I, Nitta H, Murillo A, Tozbikian G, Banks P, Parwani AV, Li Z. Identification of HER2 Immunohistochemistry-Negative, FISH-Amplified Breast Cancers and Their Response to Anti-HER2 Neoadjuvant Chemotherapy. Am J Clin Pathol. 2019 Jan 7;151(2):176-184. DOI: 10.1093/ajcp/aqy136. PMID: 30339245
  • Tozbikian G, Zynger D. A Combination of GATA3 and SOX10 is Useful for the Diagnosis of Metastatic Triple Negative Breast Cancer. Human Pathology. 2018 Nov 20 DOI: 10.1016/j.humpath.2018.11.005 PMID: 30468800
  • Quinn K, Tozbikian G, Carson W. Concurrent phyllodes tumor, eccrine carcinoma, and multinodular goiter twenty years after radiotherapy for Hodgkin lymphoma. Clinical Case Reports. 2018 Nov; 12(6). DOI: 10.1002/ccr3.1854. PMID: 30564357
  • Niazi MKK, Lin Y, Liu F, Ashok A, Marcellin MW, Tozbikian G, Gurcan MN, Bilgin A. Pathological image compression for big data image analysis: Application to hotspot detection in breast cancer. Artif Intell Med. 2018 Sep 25. pii: S0933-3657(17)30232-4. DOI: 10.1016/j.artmed.2018.09.002. PMID: 30266546
  • Niazi MKK, Senaras C, Pennell M, Arole V, Tozbikian G, Gurcan MN. Relationship between the Ki67 index and its area based approximation in breast cancer. BMC Cancer. 2018 Sep 3;18(1):867. DOI: 10.1186/s12885-018-4735-5. PMID: 3017681
  • Senaras C, Niazi MKK, Sahiner B, Pennell MP, Tozbikian G, Lozanski G, Gurcan MN. Optimized generation of high-resolution phantom images using cGAN: Application to quantification of Ki67 breast cancer images. PLoS One. 2018; 13(5). DOI: 10.1371/journal.pone.0196846. PMID: 29742125
  • Sizemore GM, Balakrishnan S, Trimboli AJ, Hammer AM, Sizemore ST, Cuitiño MC, Tozbikian G, Thies KA, Kladney RD, Shinde N, Park D, Woelke SA, Majumder S, Krishnan S, Yu L, Fernandez SA, Chakravarti A, Shields PG, White JR, Yee LD, Rosol TJ, Ludwig T, Park M, Leone G, Ostrowski MC. Stromal PTEN determines mammary epithelial response to radiotherapy Nature Communications. 2018 9:2783. DOI: 10.1038/s41467-018-05266-6. PMID: 30018330 PMCID: PMC6050339
  • Tozbikian G, Zynger DL. HER2 equivocal breast cancer that is positive by alternative probe HER2 FISH are classified as HER2 negative by Oncotype DX. The Breast Journal. 2018 Jul;24(4):535-540. DOI: 10.1111/tbj.13004. PMID: 29498449
  • Hou Y, Tozbikian G, Zynger DL, Li Z. Using the Modified Magee Equation to Identify Patients Unlikely to Benefit From the 21-Gene Recurrence Score Assay (Oncotype DX Assay). Am J Clin Pathol. 2017 Jun 1;147(6):541-548. DOI: 10.1093/ajcp/aqx008. PMID: 28449064
  • Tozbikian G, Gemignani ML, Brogi E. Specimen Identification Errors in Breast Biopsies: Age matters. Report of Two Near-Miss Events and Review of the Literature. The Breast Journal. 2017 Sep;23(5):583-588. DOI: 10.1111/tbj.12797. PMID: 28299848
  • Xian Z, Quinones AK, Tozbikian G, Zynger DL. Breast cancer biomarkers before and after neoadjuvant chemotherapy: does repeat testing impact therapeutic management? Hum Pathol. 2017 Apr; 62:215-221. DOI: 10.1016/j.humpath.2016.12.019. PMID: 28041972
  • Tozbikian G, Brogi E, Catalano J, Van Zee KJ, Kadivar M, Vallejo CE, Giri D, Murray M, Wen HY. Atypical Ductal Hyperplasia Bordering on Ductal Carcinoma In Situ. International Journal of Surgical Pathology. 2017 Apr;25(2):100-107. DOI: 10.1177/1066896916662154. PMID: 27481892
  • Spohn GP, Trotter ST, Tozbikian G, Povoski SP. Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin. BMC Dermatology. 2016 May 20;16(1):4. DOI: 10.1186/s12895-016-0041-6. PMID: 27206635 PMCID: PMC4873987
  • Overcast W, Zhang J, Zynger DL, Tozbikian G. Impact of the 2013 ASCO/CAP HER2 Revised Guidelines on HER2 Results in Breast Core Biopsies with Invasive Breast Carcinoma: A Retrospective Study. Virchows Archiv. 2016 Aug;469(2):203-12. DOI: 10.1007/s00428-016-1951-8. PMID: 27220765
  • Coffman J, Ristev G, Tozbikian G, Small RH. Separation of Perifix® FX epidural catheter components in a laboring patient. International Journal of Obstetric Anesthesia. 2016 Jan 3. DOI: 10.1016/j.ijoa.2016.01.002. PMID: 26975758
  • Tozbikian G, Brogi E, Kadota K, Catalano J, Akram M, Patil S, Ho A, Reis Filho J, Weigelt B, Norton L, Adusumilli P, Wen HY. Mesothelin Expression in Triple Negative Breast Carcinomas Correlates Significantly with Basal-like Phenotype, Distant Metastases and Decreased Survival. PLoS One. 2014 Dec 15;9 (12):PONE-D-14-40005R1. DOI: 10.1371/journal.pone.0114900. PMID: 25506917 PMCID: PMC4266616
  • Pahouja G, Wesolowski R, Reinbolt RE, Tozbikian G, Berger MJ, Mangini N, Lustberg MB. Stabilization of bone marrow infiltration by metastatic breast cancer with continuous doxorubicin. Cancer Treatment Communications. 2014 Dec 4. DOI: 10.1016/j.ctrc.2014.11.002. PMCID 25914871 PMC4408922
  • Shinohara MM, Tozbikian G, Wolfe JT, Shin SJ, Mies C, Elenitsas R. Cutaneous metastatic breast carcinoma with clear cell features. J Cutan Pathol. 2013 April 11. DOI: 10.1111/cup.12162. PMID: 23672673
  • Tozbikian G, Shen R, Suster S. Signet Ring Cell Gastric Schwannoma: Report of a New Distinctive Morphological Variant. Ann Diagn Pathol. 2008 Apr;12(2):146-52. DOI: 10.1016/j.anndiagpath.2006.12.004. PMID: 18325478