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Vijay Pancholi, PhD

Research Associate Professor

Vijay Pancholi, PhD

Phone:

614-688-8053

E-mail:

Email Dr. Pancholi

Mailing Address:

288A Tzagournis Medical Research Facility
420 W. 12th Ave
Columbus, OH 43210

Biosketch

Vijay Pancholi, Ph.D. He earned his Ph.D. in Medical Microbiology at the Post Graduate Institute of Medical Education & Research (PGIMER) in Chandigarh, India. He completed postdoctoral, training in the Department of Medicine, Mount Sinai Medical Center in New York, followed by training in the Laboratory of Bacteriology and Immunology, The Rockefeller University, New York. He was Assistant Professor at Rockefeller University from 1992 -1999. He was Associate Member/ Professor at Public Health Research Institute (PHRI)at International Center for Public Health (ICPH), New York, New Jersey ( Now Rutgers university). He joined Ohio State University as an Associate Professor in the Department of Pathology in 2005. Dr. Pancholi’s research focuses on the bacterial pathogenesis of, mechanisms of antimicrobial drug resistance in and therapeutic intervention for Gram-positive pathogens.

Academic and Medical Appointments

2013-present Associate Professor (courtesy appointment), Department of Microbial Infection & Immunity, The Ohio State University College of Medicine, Columbus, OH

2009-present Research Associate Professor, Department of Pathology, The Ohio State University College of Medicine, Columbus, OH

2005-2008 Associate Professor, Department of Pathology, The Ohio State University College of Medicine, Columbus, OH

Previous Academic Appointments

2001-2005 Associate Member/Professor, Public Health Research Institute, Newark, NJ

2001-2004 Adjunct Faculty, Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY

1993-2001 Assistant Professor, Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY

1989-1992 Junior Faculty /Research Associate, Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY

1979-1983 Tutor, Dept. of Medical Microbiology, Post-Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

1979-1984 Tutor and In-charge Emergency Clinical Microbiology Lab., P.G.I.M.E.R., Chandigarh, India

Education and Training

1986-1988 Postdoctoral Associate, Laboratory of Bacteriology and Immunology, The Rockefeller University, New York, NY

1985-1986 Postdoctoral Associate, Dept. of Medicine, Mount Sinai Medical Center, New York, NY

1979-1984 Ph.D., Medical Microbiology, Post‐Graduate Institute of Medical Education & Research, Chandigarh, India

Selected Publications

Search in PubMed

  • Krause K, Daily K, Estfanous S, Hamilton K, Badr A, Abu Khweek A, Hegazi R, Anne MN, Klamer B, Zhang X, Gavrilin MA, Pancholi V, Amer AO. Caspase-11 counteracts mitochondrial ROS-mediated clearance of Staphylococcus aureus in macrophages. EMBO Rep. 2019 Dec 5;20(12):e48109. doi: 10.15252/embr.201948109. Epub 2019 Oct 21. PubMed PMID: 31637841; PubMed Central PMCID: PMC6893291.
  • Pancholi V. Group A Streptococcus-Mediated Host Cell Signaling. Microbiol Spectr. 2019 Jan;7(1). doi:10.1128/microbiolspec.GPP3-0021-2018. PubMed PMID: 30767846.
  • Zhang, W.,Aurosree B., Gopalakrishnan, B., Joan-Miquel Balada-Llasat, J-M., Pancholi, V., Pancholi, P. The role of LpxA/C/D and pmrA/B gene systems in colistin-resistant clinical strains of Acinetobacter baumannii. Frontiers in Laboratory Medicine 1 (2017) 86–91
  • Kant S, Asthana S, Missiakas D, Pancholi V. A novel STK1-targeted small-molecule as an "antibiotic resistance breaker" against multidrug-resistant Staphylococcus aureus. Sci Rep. 2017 Jul 11;7(1):5067. doi: 10.1038/s41598-017-05314-z. PubMed PMID: 28698584; PubMed Central PMCID: PMC5505960.
  • Edgar RJ, Chen J, Kant S, Rechkina E, Rush JS, Forsberg LS, Jaehrig B, Azadi P, Tchesnokova V, Sokurenko EV, Zhu H, Korotkov KV, Pancholi V, Korotkova N. SpyB, a Small Heme-Binding Protein, Affects the Composition of the Cell Wall in Streptococcus pyogenes. Front Cell Infect Microbiol. 2016;6:126. doi: 10.3389/fcimb.2016.00126. eCollection 2016. PubMed PMID: 27790410; PubMed Central PMCID: PMC5061733.
  • Pancholi V, Caparon M. Streptococcus pyogenes Metabolism. 2016;. Review. PubMed PMID: 26866220.
  • Kant S, Agarwal S, Pancholi P, Pancholi V. The Streptococcus pyogenes orphan protein tyrosine phosphatase, SP-PTP, possesses dual specificity and essential virulence regulatory functions. Mol Microbiol. 2015 Aug;97(3):515-40. doi: 10.1111/mmi.13047. Epub 2015 May 29. PubMed PMID: 25939957.
  • Agarwal S, Agarwal S, Pancholi P, Pancholi V. Strain-specific regulatory role of eukaryote-like serine/threonine phosphatase in pneumococcal adherence. Infect Immun. 2012 Apr;80(4):1361-72. doi: 10.1128/IAI.06311-11. Epub 2012 Feb 6. PubMed PMID: 22311926; PubMed Central PMCID: PMC3318399.
  • Agarwal S, Agarwal S, Jin H, Pancholi P, Pancholi V. Serine/threonine phosphatase (SP-STP), secreted from Streptococcus pyogenes, is a pro-apoptotic protein. J Biol Chem. 2012 Mar 16;287(12):9147-67. doi: 10.1074/jbc.M111.316554. Epub 2012 Jan 19. PubMed PMID: 22262847; PubMed Central PMCID: PMC3308748.
  • Agarwal S, Agarwal S, Pancholi P, Pancholi V. Role of serine/threonine phosphatase (SP-STP) in Streptococcus pyogenes physiology and virulence. J Biol Chem. 2011 Dec 2;286(48):41368-80. doi: 10.1074/jbc.M111.286690. Epub 2011 Sep 14. PubMed PMID: 21917918; PubMed Central PMCID: PMC3308849.
  • Jin H, Agarwal S, Agarwal S, Pancholi V. Surface export of GAPDH/SDH, a glycolytic enzyme, is essential for Streptococcus pyogenes virulence. mBio. 2011;2(3):e00068-11. doi: 10.1128/mBio.00068-11. Print in 2011. PubMed PMID: 21628503; PubMed Central PMCID: PMC3104492.
  • Pancholi V, Boël G, Jin H. Streptococcus pyogenes Ser/Thr kinase-regulated cell wall hydrolase is a cell division plane-recognizing and a chain-forming virulence factor. J Biol Chem. 2010 Oct 1;285(40):30861-74. doi: 10.1074/jbc.M110.153825. Epub 2010 Jul 19. PubMed PMID: 20643653; PubMed Central PMCID: PMC2945579

Book Chapters:

  • Pancholi V. Group A Streptococcus‐mediated Host cell Signaling. In: Gram‐Positive Pathogens. 3nd ed. VA Fischetti, RP Novick, JJ Ferretti, DA Portnoy, M Braunstein, JI Rood (eds). John Wiley & Sons Ltd. West Sussex, UK. 125‐147. 2020
  • Pancholi V. GAPDH: A Cell Surface Major Virulence Determinant: In: Moonlighting Proteins: Novel Virulence Factors in Bacterial Infection. Chapter‐16. Ed: Brian Henderson. John Wiley and Sons, USA 2016.
  • Pancholi V. General Metabolism, Biosynthetic Pathways, Transport and Secretion. In: Streptococcus pyogenes: Basic Biology to Clinical Manifestation. JJ Ferretti, V Fischetti, DL Stevens (eds). eBOOK‐ NIH June 2016. http://www.ncbi.nlm.nih.gov/books/NBK333424.
  • Pancholi V. Streptococcus‐mediated Host cell Signaling. In: Gram‐Positive Pathogens. 2nd ed. VA Fischetti, R Novick, J Ferretti, D Portnoy, J Rood (eds). Washington, D.C.:ASM Press. 100‐112. 2006.
  • Pancholi V. Staphylococcal Extracellular/Surface Enzymatic Activity. In: Staphylococcal Infection and Immunity. A Honeyman, H Friedman, M Bendinelli (eds). New York: Kluwer/Plenum. 137‐154. 2001.
  • Pancholi V. Streptococci‐Mediated Host Cell Signaling. In: Gram‐Positive Pathogens. VA Fischetti, R Novick, J Ferretti, D Portnoy, J Rood (eds). Washington, D.C: ASM Publications. 87‐95. 1999.