Department of Pathology

Wei Chen, MD, PhD

Associate Professor

Wei Chen, MD, PhD

Phone:

(614) 366-1041

E-mail:

Email Dr. Chen

Mailing Address:

S301 Rhodes Hall
410W. 10th Ave
Columbus, OH 43210

Biosketch

Wei Chen, MD, Ph.D, is an Associate Professor-Clinical in the Anatomic Pathology Branch at The Ohio State University Wexner Medical Center (OSUWMC). Dr. Chen is a board-certified surgical pathologist specializing in gastrointestinal, liver and pancreaticobiliary pathology, and gynecologic pathology.

Dr. Chen's research focuses on pancreaticobiliary / liver pathology, colorectal cancer, and computer-aided diagnosis. She has given invited talks at international and local/regional levels, co-authored 7 book chapters in gastrointestinal and pancreas pathology, and published over 50 peer-reviewed journal articles.

Board Certifications

Anatomic and Clinical Pathology, American Board of Pathology

Academic and Medical Appointments

2021-Present Director, Hepato-Pancreato-Biliary Pathology, The Ohio State University, Columbus Ohio.

2018-Present Associate Director, GI/Liver Pathology Fellowship, The Ohio State University, Columbus Ohio.

2021-Present Associate Professor-Clinical, Department of Pathology, The Ohio State University, Columbus Ohio.

2018-2021 Associate Director, Liver Pathology, The Ohio State University, Columbus Ohio.

2015-2021 Assistant Professor-Clinical, Department of Pathology, The Ohio State University, Columbus Ohio.

Education and Training

2014-2015GI, Pancreas, and Liver Pathology Fellowship, The Ohio State University, Columbus, OH

2011-2014 Resident, Anatomic and Clinical Pathology, The Ohio State University, Columbus, OH

2010-2011 Resident, Anatomic and Clinical Pathology, Berkshire Medical Center, Pittsfield, MA

2000-2007 Ph.D., Dept. of Zoology/MCB program, Oregon State University, Corvallis, OR

1995-2000 Bachelor of Medicine, Peking University Health Science Center, Beijing, China

Selected Publications

Search in PubMed

Book Chapters:

  • Chen W, Jin M, Frankel W. Chapter 3: Pathology: Premalignant and malignant diseases and molecular genetics. In Current and Emerging Therapies in Pancreatic Cancer. Springer. Cham 2017, pages 49-96
  • Markow M, Chen W, Frankel W. Chapter 12: Immunohistochemical pitfalls: Common mistakes in the evaluation of Lynch syndrome. In Surgical Pathology Clinics series; Gastrointestinal Pathology: Common Questions and Diagnostic Dilemma. Elsevier. pp977-1007, 2017
  • Chen W, Frankel W. Chapter 2: Approach to epithelial neoplasms of the gastrointestinal tract. In Neoplastic Gastrointestinal Pathology. Demos Medical Publishing. pp19-37, 2016.
  • Chen W, Owens S, Frankel W. Chapter 9: Neoplasms of the small intestine. In Neoplastic Gastrointestinal Pathology. Demos Medical Publishing. pp217-247, 2016.

Journal Articles:

  • Chavez JA*, Chen W*, Freitag CE, Frankel WL. Pancreatic frozen section guides operative management with rare deferrals and errors: Five-year experience at a large academic institution. Arch Pathol Lab Med. 2021.doi: 10.5858/arpa.2020-0483-OA. *Contributed equally to the work.
  • Lu LC, Hu ZL, Frankel WL, Shen RL, Chen W, Grecula JC, Bloomston MP, Dillhoff M. Using Endoscopic Optical Coherence Tomography (Endo-OCT) to Detect and Treat Early Stage Pancreatic Cancers. Front. Oncol. 2021. https://doi.org/10.3389/fonc.2021.591484
  • Vazzano J, Frankel WL, Wolfe A, Williams T, and Chen W. Morphologic Changes Associated with Neoadjuvant-Treated Pancreatic Ductal Adenocarcinoma and Comparison of Two Tumor Regression Grading Systems. Hum. Pathol. 2020. doi: 10.1016/j.humpath.2020.11.010.
  • Ren R, Krishna S, Chen W, Frankel F, Shen R, Zhao W, Avenarius M, Garee J, Caruthers S, and Jones D. Activation of the RAS pathway through uncommon BRAF mutations in mucinous pancreatic cysts without KRAS mutation. Mod. Pathol. 2020. doi: 10.1038/s41379-020-00647-z.
  • Chen W, Hampel H, Pearlman R, Jones D, Zhao W, Alsomali M, Knight D, Frankel W. Retained Expression of Mismatch Repair Protein Is More Commonly Seen with Pathogenic Missense Than Other Mutations in Lynch Syndrome. Hum Pathol. 2020. doi: 10.1016/j.humpath.2020.07.001.
  • Wolfe A, Prabhakar D, Yildiz V, Cloyd J, Dillhoff M, Abushahin L, Diaz D, Miller E, Chen W, Frankel W, Noonan A, Williams T. Neoadjuvant Modified FOLFIRINOX versus Nab-Paclitaxel plus Gemcitabine for Borderline Resectable or Locally Advanced Pancreatic Cancer Patients who Achieved Surgical Resection. Cancer Med. 2020. doi: 10.1002/cam4.3075.
  • Fauzi M, Chen W, Knight D, Hampel H, Frankel W, Gurcan M. Tumor Budding Detection System in Whole Slide Pathology Images. J Med Syst. 2020; 44:38. doi:10.1007/s10916-019-1515-y.
  • Wolfe AR, Wald P, Webb A, Walston S, Robb R, Chen W, Vedaie M, Dillhoff M, Manilchuk A, Frankel W, Kwon W, Jang J, Williams T. A microRNA-based Signature Predicts Local-regional Failure and Overall Survival After Pancreatic Cancer Resection. Oncotarget. 2020; 11:913-923. https://doi.org/10.18632/oncotarget.27496.
  • Alsomali M, Yearsley M, Levin D, Chen W. Diagnosis of congenital hepatic fibrosis in adulthood. Am J Clin Pathol. 2020; 153(1):119-125. doi: 10.1093/ajcp/aqz140.
  • Tavolara TE, Niazi MKK, Arole V, Chen W, Frankel W, Gurcan M. A modular cGAN classification framework: Application to colorectal tumor detection. Sci Rep. 2019; 9, 18969 doi:10.1038/s41598-019-55257-w.
  • Chen W, Pearlman R, Markow M, Arnold C, Pritchard C, Knight D, Hampel H, Frankel W. MSH6 Immunohistochemical Heterogeneity in Colorectal Cancer: Comparative Sequencing from Different Tumor Areas. Hum Pathol. 2019. doi: 10.1016/j.humpath.2019.11.003.
  • Sachak T, Frankel WL, Arnold CA, Chen W. Multinucleated stromal giant cells in the gastroesophageal junctional and gastric mucosa: a retrospective study. Diagn Pathol 2019; 14: 83. doi: 10.1186/s13000-019-0860-y.
  • Chen W, Frankel W. A practical guide to biomarkers for the evaluation of colorectal cancer. Mod Pathol. 2019; 32(Suppl 1):1-15. doi: 10.1038/s41379-018-0136-1.
  • Chen W, Swanson BJ, Frankel W. Molecular genetics of microsatellite-unstable colorectal cancer for pathologists. Diagn Pathol. 2017; 12(1):24. doi: 10.1186/s13000-017-0613-8.
  • Chen W, Frankel W, Cronley K, Yu L, Zhou XP, Yearsley M. The significance of Paneth cell metaplasia in Barrett esophagus: A morphologic and clinicopathologic study. Am J Clin Pathol. 2015; 143:1-7. doi: 10.1309/AJCPVUJMCVBC9PKM.
  • Chen W, Rock JB, Yearsley MM, Ferrell LD, Frankel WL. Different collagen types show distinct rates of increase from early to late stages of hepatitis C-related liver fibrosis. Hum Pathol. 2014; 45(1):160-5.