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Weiqiang John Zhao, MD, PhD

Professor-Clinical

Weiqiang John Zhao, MD, PhD

Phone:

614-293-4210

E-mail:

Email Dr. Zhao

Office Location:

2001 Polaris Parkway, Room 2065

Mailing Address:

2001 Polaris Parkway
Room 2065
Columbus, OH 43240

Biosketch

Weiqiang Zhao, MD, PhD, is a Professor of Pathology at The Ohio State University Wexner Medical Center. He also serves as Medical Director of Polaris Molecular Laboratories of Arthur G. James Cancer Hospital. Dr. Zhao earned his MD degree from Hunan Medical College and Ph.D. from Tulane University. He completed AP/CP pathology residency at Tulane University Medical Center, New Orleans, LA. He completed clinical fellowships for Hematopathology and Molecular Genetic Pathology at Tulane University Medical Center and UT MD Anderson Cancer Center, respectively. He is board certified in AP/CP, Hematopathology and Molecular Genetic Pathology.

His research interests are in defining molecular and genetic biomarkers of Cancer (Lung, GI), Lymphoma and Leukemia, and normal and abnormal hematopoeises. Dr. Zhao received several pathology awards from CAP and Pathologists in Training at Tulane University Medical Center. He is an editorial reviewer of Frontier Medicine and Laboratory Medicine.

Board Certifications

2009 Molecular Genetic Pathology, American Board of Pathology

2008 Hematopathology, American Board of Pathology

2007 State of Ohio Board of Medicine

2005 Anatomic Pathology and Clinical Pathology, American Board of Pathology

Academic and Medical Appointments

2015-Present Medical Director, Polaris Molecular Laboratories, James Cancer Center/Hospital, The Ohio State University, Columbus, OH

Present Professor-Clinical, Department of Pathology, The Ohio State University, Columbus, OH

Education and Training

2006-2007 Fellow, Molecular Genetic Pathology, MDACC, Texas, USA

2005-2006 Fellow, Hematopathology, Tulane University Medical Center, New Orleans, LA, and MDACC, Texas, USA

2000-2005 Resident, Pathology, Tulane University Medical Center, New Orleans, LA, USA

1985-1988 Ph.D, Molecular Biology, Tulane University, New Orleans, LA, USA

1978-1982 M.D., Hunan Medical College, Changsha, China

Selected Publications

Search in PubMed

  • Reddy NM, Bast MA, Vose JM, Kruczek KR, Smith SE, Patel P, Hernandez-Ilizaliturri F, Karmali R, Rajguru S, Yang DT, Maly JJ, Blum KA, Zhao W, Vanslambrouck C, Nabhan C. Sole rearrangement but not amplification of MYC is associated with a poor prognosis in patients with diffuse large B cell lymphoma and B cell lymphoma unclassifiable. Br J Haematol. 2016 Jul 29. doi: 10.1111/bjh.14282. [Epub ahead of print] PubMed PMID: 27469075.
  • Siegele BJ, Shilo K, Chao BH, Carbone DP, Zhao W, Ioffe O, Franklin WA, Edelman MJ, Aisner DL. Epidermal growth factor receptor (EGFR) mutations in small cell lung cancers: Two cases and a review of the literature. Lung Cancer. 2016 May;95:65-72. doi: 10.1016/j.lungcan.2016.02.012. Epub 2016 Feb 26. PubMed PMID: 27040854
  • Lehman NL, Hattab EM, Mobley BC, Usubalieva A, Schniederjan MJ, McLendon RE, Paulus W, Rushing EJ, Georgescu MM, Couce M, Dulai MS, Cohen ML, Pierson CR, Raisanen JM, Martin SE, Lehman TD, Lipp ES, Bonnin JM, Al-Abbadi MA, Kenworthy K, Zhao K, Mohamed N, Zhang G, Zhao W. Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults. Neuro Oncol. 2016 Jul 14. pii: now118. [Epub ahead of print] PubMed PMID: 27416954
  • Villalona-Calero MA, Lam E, Otterson GA, Zhao W, Timmons M, Subramaniam D, Hade EM, Gill GM, Coffey M, Selvaggi G, Bertino E, Chao B, Knopp MV. Oncolytic reovirus in combination with chemotherapy in metastatic or recurrent non-small cell lung cancer patients with KRAS-activated tumors. Cancer. 2015 Dec 28. [Epub ahead of print] PMID: 26709987.
  • Araujo LH, Timmers C, Shilo K, Zhao W, Zhang J, Yu L, Natarajan TG, Miller CJ, Yilmaz AS, Liu T, Amann J, Lapa E Silva JR, Ferreira CG, Carbone DP. Impact of pre-analytical variables on cancer targeted gene sequencing efficiency. PLoS One. 2015 Nov 25;10(11):e0143092. PMID: 26605948. PMCID: PMC4659597
  • Ozkan E, West A, Dedelow JA, Chu BF, Zhao W, Yildiz VO, Otterson GA, Shilo K, Ghosh S, King M, White RD, Erdal BS. CT gray-level texture analysis as a quantitative imaging biomarker of epidermal growth factor receptor mutation status in adenocarcinoma of the lung. AJR Am J Roentgenol. 2015 Nov;205(5):1016-25. PMID: 26496549
  • Araujo LH, Lammers PE, Matthews-Smith V, Eisenberg R, Gonzalez A, Schwartz AG, Timmers C, Shilo K, Zhao W, Natarajan TG, Zhang J, Yilmaz AS, Liu T, Coombes K, Carbone DP. Somatic mutation spectrum of non-small cell lung cancer in African Americans: a pooled analysis. J Thorac Oncol. 2015 Aug 21. [Epub ahead of print.] PMID: 26301800
  • Mikhail S, Ciombor K, Noonan A, Wu C, Goldberg R, Zhao W, Wei L, Mathey K, Yereb M, Timmers C, Bekaii-Saab T. Upfront molecular testing in patients with advanced gastro-esophageal cancer: Is it time yet? Oncotarget. 2015 Jun 10. [Epub ahead of print.] PMID: 26082439
  • Byrd JC, Furman RR, Coutre SE, Burger JA, Blum KA, Coleman M, Wierda WG, Jones JA, Zhao W, Heerema NA, Johnson AJ, Shaw Y, Bilotti E, Zhou C, James DF, O’Brian S. Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib. Blood. 2015 Apr 16;125(16): 2497-506. Epub 2015 Feb 19. PMID: 25700432
  • Blachly JS, Ruppert AS, Zhao W, Long S, Flynn J, Flinn I, Jones J, Maddocks K, Andritsos L, Ghia EM, Rassenti LZ, Kipps TJ, de la Chapelle A, Byrd JC. Immunoglobin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia. Proc Natl Acad Sci USA. 2015 Apr7;112(14): 4322-7. Epub 2015 Mar 18. PMID: 25787252. PMCID: PMC4394264
  • Maddocks KJ, Ruppert AS, Lozanski G, Heerema NA, Zhao W, Abruzzo L, Lozanski A, Davis M, Gordon A, Smith LL, Mantel R, Jones JA, Flynn JM, Jaglowski SM, Andritsos LA, Awan F, Blum KA, Grever MR, Johnson AJ, Byrd JC, Woyach JA. Etiology of Ibrutinib therapy discontinuation and outcomes in patients with chronic lymphocyctic leukemia. JAMA Oncol. 2015 Apr 1;1(1):80-7. PMID: 26182309
  • Tang Y, Zhang G, Baird M, Racke F, Zhao W. A novel role of CYP2E1 in human megakaryocyte development. In Vivo. 2014 Nov-Dec; 28(6):1077-1084. PubMed PMID: 25398802
  • Zhao W, Damodaran S, Villalona-Calero MA. From single-gene to multiplex analysis in lung cancer, challenges and accomplishments: a review of a single institution’s experience. Lung Cancer Manag. 2014 Aug 1;4(3): 315-324. PMID: 25580159. PMCID: PMC4286371
  • Claus R, Lucas DM, Ruppert AS, Williams KE, Weng D, Patterson K, Zucknick M, Oakes CC, Rassenti LZ, Greaves AW, Geyer S, Weirda WG, Brown JR, Gribben JG, Barrientos JC, Rai KR, Kay NE, Kipps TJ, Shields P, Zhao W, Grever MR, Plass C, Byrd JC. Validation of Zap-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia. Blood. 2014 Jul 3;124(1):42-8. Epub 2014 May 27. PMID: 24868078. PMCID: PMC4125353
  • Yilmaz A, Davis M, Zhao W. Effect of the R406H substitution on the normal function of CHEK2. Adv Biosci & Biotech. 2014 Mar;5:386-392. Published online in SciRes. http://dx.doi.org/10.4236/abb.2014.54046
  • Rajappannair L, Lam E, Benson D, Racke F, Devine S, Zhao W. Collision anaplastic large cell lymphoma (T-cell/histiocyte rich) and diffuse large B-cell lymphoma: A pathological and clinical evaluation. J Cancer Therapy. 2012; 3:1060-65. PMID: 23066397.
  • Kanagal-Shamanna R, Zhao W, Vadhan-Raj S, Nguyen MH, Fernandez MH, Medeiros LJ, Bueso-Ramos CE. Over-expression of CYP2E1 mRNA and protein: implications of xenobiotic induced damage in patients with de novo acute myeloid leukemia with inv(16)(p131q22); CBFβ-MYH11. Int J Environ Res Public Health. 2012 Aug;9(8):2788-2800. PMID: 23066397. PMCID: PMC3447587
  • Zhao W, Huang CC, Otterson GA, Leon ME, Tang Y, Shilo K, Villalona MA. Altered p16(INK4) and RB1 expressions are associated with poor prognosis in patients with nonsmall cell lung cancer. J Oncol. 2012 Apr;2012: 957437. PMID: 22619677. PMCID: PMC3350860
  • Christian B, Zhao W, Hamadani M, Sotomayor EM, Navarro W, Devine SM, Racke F, Blum KA. Mantle cell lymphoma 12 years after allogeneic bone marrow transplantation occurring simultaneously in recipient and donor. J Clin Oncol. 2010 Nov 1;28(31):e629-32. PMID: 20733121
  • Zhao W, Bueso-Ramos CE, Verstovsek S, Barkoh BA, Khitamy AA, Jones D. Quantitative profiling of codon 816 KIT mutations can aid in the classification of systemic mast cell disease. Leukemia. 2007 Jul;21(7):1574-6. PMID: 17410189