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Jian Zhu, PhD


Jian Zhu, PhD




Email Dr. Zhu

Mailing Address:

351C Comprehensive Cancer Ctr
Columbus, OH 43210

Dr. Zhu's Lab


Our lab studies the epigenetic (DNA and histone methylation) and epitranscriptional (RNA methylation) aspects in viral infections and antiviral immune responses. We work at the interface of virology, immunology, genetics, cellular and molecular biology. We will identify novel host regulators that control viral infections, persistence, and antiviral immune responses, particularly for HIV, herpesviruses (EBV, KSHV), and respiratory viruses (SARS-CoV-2, influenza), by using functional genomic (RNAi, CRISPR/Cas9), quantitative proteomic (MS, PLATO), as well as single-cell multiomics approaches. We will further dissect the functions and mechanisms of key host regulators using classic cell and/or animal models of viral infections. Newly developed small-molecule compounds targeting host regulators will be investigated as the next-generation antiviral reagents and/or immune modulators.

Areas of Expertise:

  • Viral infections, persistence, and antiviral immune responses
  • Epigenetic and epitranscriptional regulation of host-virus interactions
  • Chemical inhibition of epigenetic and epitranscriptional regulators
  • Systematic biology approaches for gene discovery
  • AIDS associated malignancies (head and neck cancers, lymphomas) and pathogenesis

Academic and Medical Appointments

2024-Present Professor (with Tenure), Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH

2018-2024 Associate Professor (with Tenure), Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH

2013-2018 Assistant Professor, Department of Microbiology & Immunology, University of Rochester Medical Center, Rochester, NY

Education and Training

Postdoc, Brigham and Women’s Hospital at Harvard Medical School

PhD, Johns Hopkins University School of Medicine

MS, University of Nebraska Medical Center

BS, Peking University Health Science Center

Selected Publications

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