Department of Pathology

Jian Zhu, PhD

Associate Professor

Jian Zhu, PhD




Email Dr. Zhu

Office Location:

119 Hamilton Hall

Mailing Address:

119 Hamilton Hall
1645 Neil Ave
Columbus, OH 43210

Dr. Zhu's Lab


Our lab studies the epigenetic and epitranscriptional aspects in viral infections and antiviral immune responses. We work at the interface of virology, immunology, genetics, cellular and molecular biology. We will identify novel host regulators that control viral persistence and antiviral immune responses, particularly for HIV, herpesviruses, and newly emerging viruses (ZIKV, SARS-CoV-2), by using modern functional genomic (RNAi, CRISPR/Cas9) and quantitative proteomic (MS, PLATO) approaches. We will further dissect the mechanistic functions of these key host regulators using classic cell and/or animal models of viral infections. Newly developed small-molecule compounds targeting host regulators will also be investigated as the next-generation antiviral reagents and/or immune modulators.

Areas of Expertise:

  • Viral persistence and antiviral immune responses
  • Epigenetic and epitranscriptional regulation of host-virus interactions
  • Chemical inhibition of epigenetic and epitranscriptional regulators
  • Systematic biology approaches for gene discovery
  • AIDS associated malignancies and pathogenesis


Academic and Medical Appointments

2018-Present Associate Professor (with Tenure), Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH

2013-2018 Assistant Professor, Department of Microbiology & Immunology, University of Rochester Medical Center, Rochester, NY

Education and Training

Postdoc, Brigham and Women’s Hospital at Harvard Medical School

PhD, Johns Hopkins University School of Medicine

MS, University of Nebraska Medical Center

BS, Peking University Health Science Center

Selected Publications

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