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DIVISIONS
Experimental Pathology
Xue-Feng Bai, MD, PhD
Sujit Basu, MD, PhD
Ramesh Ganju, PhD
Tatiana Oberyszyn, PhD
Steve Oghumu, PhD
Vijay Pancholi, PhD
Netty Santoso, PhD
Abhay Satoskar, MD, PhD
Anna Vilgelm, MD, PhD
James W. Waldman, PhD
Traci Wilgus, PhD
Jian Zhu, PhD
Ramesh Ganju, PhD
810 Biomedical Research Tower 460 W 12th Ave Columbus, OH 43210
Link to director's bio
EXPERIMENTAL PATHOLOGY
Jian Zhu, PhD
Our lab studies the epigenetic (DNA and histone methylation) and epitranscriptional (RNA methylation) aspects in viral infections and antiviral immune responses. We work at the interface of virology, immunology, genetics, cellular and molecular biology. We will identify novel host regulators that control viral infections, persistence, and antiviral immune responses, particularly for HIV, herpesviruses (EBV, KSHV), and respiratory viruses (SARS-CoV-2, influenza), by using functional genomic (RNAi, CRISPR/Cas9), quantitative proteomic (MS, PLATO), as well as single-cell multiomics approaches. We will further dissect the functions and mechanisms of key host regulators using classic cell and/or animal models of viral infections. Newly developed small-molecule compounds targeting host regulators will be investigated as the next-generation antiviral reagents and/or immune modulators.
Areas of Expertise:
Viral infections, persistence, and antiviral immune responses
Epigenetic and epitranscriptional regulation of host-virus interactions
Chemical inhibition of epigenetic and epitranscriptional regulators
Systematic biology approaches for gene discovery
AIDS associated malignancies (head and neck cancers, lymphomas) and pathogenesis
Dr. Zhu's Lab